HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20932831
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2, PH~PH, PH~RA, SH2~SH2, PH~SH3_1, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 540
+	Hs
		548634 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		580990 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ITK_HUMAN (237-535): 7.09e-58: 205: 17.14
+	Mm
		623690 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		TEC_MOUSE (237-539): 1.45e-52: 190: 13.06
+	Hs
		580916 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		412000 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Bt
		439895 PLCG1_BOVIN (1-1290): 0: 1305: 96.82		PLCG1_BOVIN (238-540): 5.91e-43: 166: 17.67
+	Rn
		499156 PLCG1_RAT (1-1290): 0: 1299: 96.90		PLCG1_RAT (238-540): 8.25e-43: 166: 17.98
+	Hs
		580972 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Mm
		1141132 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		GRB2_MOUSE (435-523): 7.59e-28: 112: 31.46
+	Hs
		580985 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Rn
		499159 PLCG1_RAT (1-1290): 0: 1299: 96.90		GRB2_RAT (435-523): 6.87e-28: 112: 31.46
+	Hs
		580936 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		580938 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79
+	Xl
		60960 A5LHG3_XENLA (7-1290): 0: 1239: 80.31		GRB2A_XENLA (435-523): 7.29e-28: 113: 31.46
+	Mm
		729760 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		BTK_MOUSE (237-537): 1.45e-49: 183: 11.20
+	Mm
		639456 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		LYN_MOUSE (351-539): 3.46e-41: 157: 19.90
+	Hs
		433564 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Mm
		763400 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		FYN_MOUSE (373-537): 7.01e-41: 156: 20.23
+	Hs
		411992 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Mm
		557351 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		BLK_MOUSE (362-539): 2.98e-40: 154: 23.00