HitPredict

Interactor 1: VCAM1 (P19320)
Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Gene: VCAM1

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	19738201, 22623428
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0050839 - cell adhesion molecule binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 739 Hs			1 1824
+	Hs
		234495 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		876457 TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		581725 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		581740 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67
+	Dm
		52366 A1Z7J1_DROME (35-621): 5.09e-63: 231: 17.83		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Mm
		1143386 NRCAM_MOUSE (5-738): 7.72e-33: 138: 11.14		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		524114 CNTN1_MOUSE (422-735): 1.5e-30: 131: 15.06		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		234522 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		DLG2_HUMAN (936-1143): 2.64e-33: 142: 24.55
+	Hs
		234499 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Dm
		51866 A1Z6X2_DROME (92-531): 1.81e-14: 80: 14.91		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Dm
		113773 Q9W4Y3_DROME (27-669): 6.43e-12: 71.6: 22.21		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Dm
		113267 Q8IRV8_DROME (27-434): 8.79e-12: 71.2: 23.87		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Hs
		234509 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Dm
		65325 OBSCN_DROME (597-710): 6.63e-10: 65: 13.22		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Hs
		234520 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67
+	Ce
		103468 TTN1_CAEEL (225-400): 2.34e-10: 66.5: 15.20		DLG1_CAEEL (1010-1092): 1.62e-13: 78.3: 27.06
+	Hs
		1068678 MXRA5_HUMAN (4-113): 5.56e-12: 71.9: 12.93		PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67