HitPredict

Interactor 1: VCAM1 (P19320)
Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Gene: VCAM1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	19738201, 22623428
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 739 Hs			1 217
+	Hs
		581877 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		433249 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		722901 CD22_MOUSE (23-406): 2.03e-35: 146: 18.62		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		590607 CD22_HUMAN (10-405): 1.39e-35: 146: 17.40		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		433742 PTK7_HUMAN (10-610): 1.61e-82: 285: 15.24		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		297885 NFASC_HUMAN (511-735): 1.03e-17: 90: 16.27		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924478 PGBM_HUMAN (192-335): 8.23e-10: 64.6: 17.11		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		434111 ROBO1_HUMAN (8-353): 3.83e-54: 204: 16.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Dm
		219802 O44924_DROME (8-503): 4.87e-39: 158: 14.21		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		433569 CD22_HUMAN (10-405): 1.39e-35: 146: 17.40		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		297883 NFASC_HUMAN (511-735): 1.03e-17: 90: 16.27		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		297880 NFASC_HUMAN (511-735): 1.03e-17: 90: 16.27		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		234472 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		297881 NFASC_HUMAN (511-735): 1.03e-17: 90: 16.27		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		434019 ROBO2_HUMAN (19-529): 4.08e-16: 85: 14.59		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		412004 MAG_HUMAN (345-701): 4.3e-13: 74.7: 25.96		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		855816 TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18