HitPredict

Interactor 1: VCAM1 (P19320)
Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Gene: VCAM1

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	19738201, 22623428
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 739 Hs			1 2541
+	Hs
		581890 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		MACF1_HUMAN (404-2519): 9.43e-159: 555: 11.11
+	Hs
		255284 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		HIP1R_HUMAN (1834-2532): 3.66e-139: 467: 19.78
+	Hs
		124368 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		HIP1_HUMAN (1798-2532): 2.31e-117: 402: 20.27
+	Hs
		581462 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		PTN4_HUMAN (61-728): 1.45e-108: 373: 13.45
+	Hs
		546923 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		581782 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		URP2_HUMAN (200-416): 3.61e-52: 199: 23.74
+	Mm
		640203 VCAM1_MOUSE (1-739): 1.03e-147: 450: 75.91		RADI_MOUSE (163-404): 1.04e-56: 210: 22.27
+	Hs
		581442 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		MOES_HUMAN (163-404): 1.04e-51: 195: 23.05
+	Hs
		234595 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		MACF1_HUMAN (404-2519): 9.43e-159: 555: 11.11
+	Hs
		581740 VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		663992 ICAM5_HUMAN (307-697): 2.93e-10: 65.7: 20.87		PTN4_HUMAN (61-728): 1.45e-108: 373: 13.45
+	Dm
		65329 OBSCN_DROME (597-710): 6.63e-10: 65: 13.22		MERH_DROME (83-671): 4.07e-109: 365: 18.32
+	Hs
		546947 L1CAM_HUMAN (4-739): 1.03e-29: 128: 11.41		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		234481 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		719447 PGBM_HUMAN (192-335): 8.23e-10: 64.6: 17.11		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		547278 ICAM5_HUMAN (307-697): 2.93e-10: 65.7: 20.87		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		234520 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		1068678 MXRA5_HUMAN (4-113): 5.56e-12: 71.9: 12.93		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		234503 DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87		DYST_HUMAN (422-2075): 3.73e-15: 84.9: 9.63
+	Ce
		136791 UNC89_CAEEL (211-390): 2.72e-10: 66.5: 14.43		HUM6_CAEEL (78-421): 4.37e-20: 100: 20.00