Interactor 1: TOP2 (P15348)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2
Interactor 2: MLE (P24785)
Dosage compensation regulator mle (EC 3.6.4.13) (Protein male-less) (Protein maleless) (Protein no action potential)
Gene: MLE
Species: Drosophila melanogaster
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23989663 |
| Identification Methods | affinity chromatography technology |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DEAD~Toprim |
| Common GO terms | GO:0003682 - chromatin binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005694 - chromosome GO:0016887 - ATP hydrolysis activity |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
