HitPredict - High confidence protein-protein interactions

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	28205554, 8077196, 10875917, 21988832, 14743216, 7758105
Identification Methods	fluorescent resonance energy transfer, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Death~Death, TNFR_c6~TNFR_c6
Common GO terms	GO:0000139 - Golgi membrane GO:0002947 - tumor necrosis factor receptor superfamily complex GO:0003176 - aortic valve development GO:0003177 - pulmonary valve development GO:0003332 - negative regulation of extracellular matrix constituent secretion and 32 others more... GO:0005031 - tumor necrosis factor receptor activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0006366 - transcription by RNA polymerase II GO:0006693 - prostaglandin metabolic process GO:0006954 - inflammatory response GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0009986 - cell surface GO:0010614 - negative regulation of cardiac muscle hypertrophy GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway GO:0016020 - membrane GO:0019221 - cytokine-mediated signaling pathway GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0034250 - positive regulation of amide metabolic process GO:0042531 - positive regulation of tyrosine phosphorylation of STAT protein GO:0042742 - defense response to bacterium GO:0043120 - tumor necrosis factor binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043235 - receptor complex GO:0045121 - membrane raft GO:0045834 - positive regulation of lipid metabolic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050728 - negative regulation of inflammatory response GO:0050729 - positive regulation of inflammatory response GO:0071260 - cellular response to mechanical stimulus GO:0072659 - protein localization to plasma membrane GO:1900119 - positive regulation of execution phase of apoptosis GO:1902339 - positive regulation of apoptotic process involved in morphogenesis GO:1903140 - regulation of establishment of endothelial barrier GO:1905038 - regulation of membrane lipid metabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	455
Hs

1	455

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Last updated: 15 Jul 2024