Protein: DPOE
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)

Gene: DPOE, POL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P21951

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000278 - mitotic cell cycle
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

642007

DPB2
DNA polymerase epsilon subunit B

25

4

Small-scale

0.991

High

642020

MCM4
DNA replication licensing factor MCM4

4

13

Small-scale

0.878

High

561284

DPOLA
DNA polymerase alpha catalytic subunit A

3

3

Small-scale

0.857

High

642018

MCM2
DNA replication licensing factor MCM2

3

11

Small-scale

0.847

High

642006

MCM3
DNA replication licensing factor MCM3

3

11

Small-scale

0.834

High

642074

DPB4
DNA polymerase epsilon subunit D

16

2

Small-scale

0.762

High

642019

MCM5
Minichromosome maintenance protein 5

2

11

Small-scale

0.755

High

642060

CTF18
Chromosome transmission fidelity protein 18

6

3

Small-scale

0.740

High

642010

DCC1
Sister chromatid cohesion protein DCC1

2

0

Small-scale

0.728

High

642012

DPB3
DNA polymerase epsilon subunit C

16

0

Small-scale

0.728

High

642071

SLD5
DNA replication complex GINS protein SLD5

6

7

Small-scale

0.721

High

521108

PRI1
DNA primase small subunit

3

4

Small-scale

0.674

High

632838

PRI2
DNA primase large subunit

3

3

Small-scale

0.664

High

642034

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.647

High

642061

MCM6
DNA replication licensing factor MCM6

1

11

Small-scale

0.647

High

381399

H2B2
Histone H2B.2

3

6

Small-scale

0.643

High

642057

DPB11
DNA replication regulator DPB11

3

1

Small-scale

0.642

High

642079

CDC45
Cell division control protein 45

3

4

Small-scale

0.641

High

642000

DPOE
DNA polymerase epsilon catalytic subunit A

1

4

Small-scale

0.621

High

642011

MRC1
Mediator of replication checkpoint protein 1

2

0

Small-scale

0.605

High

453894

IF4E
Eukaryotic translation initiation factor 4E

2

0

High-throughput

0.602

High

642047

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

0

High-throughput

0.595

High

642022

SPT16
FACT complex subunit SPT16

2

1

Small-scale

0.584

High

642039

RRM3
ATP-dependent DNA helicase RRM3

2

2

Small-scale

0.584

High

642055

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

642031

SLD2
DNA replication regulator SLD2

2

0

Small-scale

0.569

High

642023

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

2

0

High-throughput

0.563

High

642042

RT107
Regulator of Ty1 transposition protein 107

1

2

Small-scale

0.552

High

642064

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.552

High

523060

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.552

High

543817

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.552

High

642050

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

642037

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.537

High

642015

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

1

High-throughput

0.537

High

419596

H2A2
Histone H2A.2

1

1

High-throughput

0.536

High

585851

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

358965

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

642025

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.513

High

642029

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.513

High

642058

TRF5
Poly(A) RNA polymerase protein 1

1

1

Small-scale

0.504

High

364330

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.501

High

602317

PHO85
Cyclin-dependent protein kinase PHO85

1

6

Small-scale

0.501

High

642001

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.501

High

642003

KC12
Casein kinase I homolog 2

1

2

Small-scale

0.501

High

642004

BUR1
Serine/threonine-protein kinase BUR1

1

5

Small-scale

0.501

High

642017

HRR25
Casein kinase I homolog HRR25

1

1

Small-scale

0.501

High

642035

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

3

Small-scale

0.501

High

642048

KC13
Casein kinase I homolog 3

1

2

Small-scale

0.501

High

642052

PSF2
DNA replication complex GINS protein PSF2

1

1

Small-scale

0.501

High

642082

PSF3
DNA replication complex GINS protein PSF3

1

1

Small-scale

0.501

High

642085

PSF1
DNA replication complex GINS protein PSF1

1

2

Small-scale

0.501

High

642038

INM1
Inositol monophosphatase 1

1

0

High-throughput

0.493

High

642043

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

578849

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.489

High

642028

SMC1
Structural maintenance of chromosomes protein 1

1

2

Small-scale

0.481

High

642084

SMT3
Ubiquitin-like protein SMT3

1

2

Small-scale

0.481

High

642076

RT103
Regulator of Ty1 transposition protein 103

1

0

Small-scale

0.480

High

380966

H2B1
Histone H2B.1

1

6

Small-scale

0.479

High

434825

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

594186

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

637167

PWP1
Periodic tryptophan protein 1

1

3

High-throughput

0.479

High

642014

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

642016

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

642021

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

642026

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

642033

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

642036

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.479

High

642041

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

2

Small-scale

0.479

High

642054

MPH1
ATP-dependent DNA helicase MPH1

1

2

High-throughput

0.479

High

642062

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

642065

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

642066

H3
Histone H3

1

7

Small-scale

0.479

High

642068

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

642070

CTF4
DNA polymerase alpha-binding protein

1

7

Small-scale

0.479

High

642072

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

642075

POB3
FACT complex subunit POB3

1

3

Small-scale

0.479

High

642080

SMC5
Structural maintenance of chromosomes protein 5

1

3

Small-scale

0.479

High

642083

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.479

High

614999

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.458

High

642005

SPT6
Transcription elongation factor SPT6

1

0

Small-scale

0.458

High

642032

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

642053

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

642073

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.458

High

642002

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

Small-scale

0.457

High

642013

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

Small-scale

0.457

High

525923

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

642009

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

642024

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

642040

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

642044

CAJ1
Protein CAJ1

1

4

High-throughput

0.445

High

642051

RAD26
DNA repair and recombination protein RAD26

1

4

Small-scale

0.445

High

435774

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

642008

BPH1
Beige protein homolog 1

1

1

High-throughput

0.437

High

642045

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

642067

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

642078

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

510194

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.407

High

592011

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

642030

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

642049

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.407

High

642077

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

642046

SLN1
Osmosensing histidine protein kinase SLN1

1

0

Small-scale

0.261

Low

642063

SSK2
MAP kinase kinase kinase SSK2

1

0

Small-scale

0.261

Low

433448

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

513629

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

569907

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

642027

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

642059

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

642081

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

394239

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

642056

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

642069

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025