HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15707590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0045121 - membrane raft
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 906
+	Hs
		154309 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		121443 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		192580 TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		610232 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610549 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		154355 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		554265 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		154304 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Mm
		648961 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		ASPP1_MOUSE (429-870): 1.7e-09: 63.8: 11.96