HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	30420664, 18939944, 37085671, 19815541
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~Death
Common GO terms	GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 604
+	Hs
		584398 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Mm
		626867 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		BIRC2_MOUSE (3-604): 0: 619: 70.20
+	Hs
		738662 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		738663 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Mm
		140023 TNR3_MOUSE (20-331): 1.61e-54: 189: 23.44		BIRC3_MOUSE (3-604): 0: 662: 73.92
+	Hs
		591324 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Mm
		140020 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		BIRC3_MOUSE (3-604): 0: 662: 73.92
+	Hs
		591325 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		639581 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Mm
		648960 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		BIRC2_MOUSE (3-604): 0: 619: 70.20
+	Hs
		645799 CD27_HUMAN (42-281): 3.74e-29: 116: 16.87		BIRC2_HUMAN (2-604): 0: 643: 72.31