Protein: SYH
Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)

Gene: SYH, HTS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 47
UniProt ID: P07263

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0004812 - aminoacyl-tRNA ligase activity
GO:0004821 - histidine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

454171

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.636

High

416063

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.618

High

454162

SYG
Glycine--tRNA ligase 1, mitochondrial

1

2

High-throughput

0.618

High

454165

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.618

High

392017

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.614

High

454169

SSB2
Ribosome-associated molecular chaperone SSB2

3

6

High-throughput

0.611

High

454151

SIS1
Protein SIS1

2

2

High-throughput

0.571

High

454167

SSZ1
Ribosome-associated complex subunit SSZ1

2

3

High-throughput

0.571

High

454144

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

454161

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.513

High

454177

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

416179

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

454148

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

454149

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

454150

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

454157

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

454163

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

454164

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

454166

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

454174

SPC98
Spindle pole body component SPC98

1

1

High-throughput

0.479

High

368850

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

454147

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

454152

RBSK
Ribokinase

1

0

High-throughput

0.458

High

454154

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

454156

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

454159

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

454168

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

454170

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.458

High

454173

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

454175

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.458

High

454176

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

454180

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

454181

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.458

High

454182

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

454184

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

454160

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.457

High

454145

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

454146

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

454153

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

454172

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

454179

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.438

High

454155

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

454183

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

454158

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

High-throughput

0.249

Low

454178

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

454185

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.249

Low

454186

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025