HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: TRADD (Q15628)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 23429285, 8565075, 15310755, 24758719, 27552911, 28514442, 30420664, 29108854, 9915703, 10187805, 16919273, 9082980, 32968279, 33961781, 8612133, 8943045, 18939944, 34839354, 37085671, 18776134 and 19 others

more...
Identification Methods affinity chromatography technology, two hybrid, experimental interaction detection, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0005886 - plasma membrane
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 2 others

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Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 455
Hs

1 312
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024