Protein: DLG2
Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

Gene: DLG2
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q15700

Gene Ontology (top 5):
GO:0004385 - GMP kinase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0007268 - chemical synaptic transmission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006071

DLG4
Disks large homolog 4

2

17

Small-scale

0.793

High

1152420

PKHA2
Pleckstrin homology domain-containing family A member 2

2

7

High-throughput

0.783

High

249141

DSCAM
Cell adhesion molecule DSCAM

1

11

High-throughput

0.698

High

1152416

DLG3
Disks large homolog 3

1

18

High-throughput

0.691

High

1145735

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.656

High

1098522

NMDE2
Glutamate receptor ionotropic, NMDA 2B

3

20

Small-scale

0.648

High

967754

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

Small-scale

0.647

High

713168

NOS1
Nitric oxide synthase 1

1

4

Small-scale

0.621

High

845654

MUC18
Cell surface glycoprotein MUC18

1

11

High-throughput

0.618

High

1091503

DLG1
Disks large homolog 1

1

18

High-throughput

0.618

High

350660

DLGP3
Disks large-associated protein 3

2

20

High-throughput

0.606

High

969239

RS8
Small ribosomal subunit protein eS8

2

1

High-throughput

0.606

High

1152415

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

1

High-throughput

0.606

High

1152422

DLGP2
Disks large-associated protein 2

2

20

High-throughput

0.606

High

154397

DLGP1
Disks large-associated protein 1

2

20

Small-scale

0.586

High

1152412

FA2H
Fatty acid 2-hydroxylase

2

0

High-throughput

0.580

High

1152423

SPB13
Serpin B13

2

0

High-throughput

0.580

High

399577

VTNC
Vitronectin

2

1

High-throughput

0.553

High

664976

ERD21
ER lumen protein-retaining receptor 1

2

1

High-throughput

0.553

High

700417

AOAH
Acyloxyacyl hydrolase

2

1

High-throughput

0.553

High

1152419

RPF2
Ribosome production factor 2 homolog

2

1

High-throughput

0.553

High

105990

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

869487

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

1

Small-scale

0.501

High

1022613

LRP2
Low-density lipoprotein receptor-related protein 2

1

8

Small-scale

0.481

High

1088771

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

20

Small-scale

0.481

High

1152413

NLGN1
Neuroligin-1

1

19

Small-scale

0.481

High

1152414

NLGN2
Neuroligin-2

1

19

Small-scale

0.481

High

1152418

SEM4C
Semaphorin-4C

1

7

Small-scale

0.481

High

1152421

NLGN3
Neuroligin-3

1

19

Small-scale

0.481

High

138126

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

289555

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

1

High-throughput

0.479

High

338010

ABCA1
Phospholipid-transporting ATPase ABCA1

1

1

Small-scale

0.479

High

605519

SYN1
Synapsin-1

1

7

High-throughput

0.479

High

648776

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

20

Small-scale

0.479

High

661271

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

11

Small-scale

0.479

High

752044

GCYA2
Guanylate cyclase soluble subunit alpha-2

1

8

Small-scale

0.479

High

870032

KCNJ4
Inward rectifier potassium channel 4

1

20

Small-scale

0.479

High

991546

DYL1
Dynein light chain 1, cytoplasmic

1

5

Small-scale

0.479

High

1008620

MAP1A
Microtubule-associated protein 1A

1

10

Small-scale

0.479

High

1024049

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

1032586

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

10

Small-scale

0.479

High

1127299

KCJ12
ATP-sensitive inward rectifier potassium channel 12

1

20

Small-scale

0.479

High

1152417

DYL2
Dynein light chain 2, cytoplasmic

1

5

Small-scale

0.479

High

1152411

Q6IS01
DLGAP1 protein

1

20

High-throughput

0.470

High

947200

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

958951

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

404803

PRIO
Major prion protein

1

3

High-throughput

0.445

High

1059847

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

Small-scale

0.408

High

518954

RNAS2
Non-secretory ribonuclease

2

0

High-throughput

0.316

High

558977

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025