HitPredict

Interactor 1: ERCC3 (P19447)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.763

The method score is based on:

Property Details
Experiments 28514442, 26340423, 15220921, 33453189, 33961781, 17643375, 28977422, 29568061, 9130708, 8521393, 35271311, 32707033, 36736316, 8692841, 10082552, 23602568, unassigned1655
Identification Methods affinity chromatography technology, biochemical, pull down, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000439 - transcription factor TFIIH core complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex
and 3 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 782
Hs

1 346
+ Dm
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At

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Last updated: 15 Jul 2024