Protein: GRAP
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)

Gene: GRAP, drk
Organism: Drosophila melanogaster
Interactions: 110
UniProt ID: Q08012

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005118 - sevenless binding
GO:0005154 - epidermal growth factor receptor binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688355

SOS
Protein son of sevenless

6

20

Small-scale

0.944

High

409162

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.907

High

1061478

DOS
Protein daughter of sevenless

3

20

Small-scale

0.855

High

117901

M9MRE1
PDGF- and VEGF-receptor related, isoform K

3

20

Small-scale

0.829

High

693526

DYN
Dynamin

2

20

Small-scale

0.806

High

561264

7LESS
Protein sevenless

2

20

Small-scale

0.768

High

1061439

Q9V3V3
protein-tyrosine-phosphatase

3

20

High-throughput

0.731

High

711013

CSW
Tyrosine-protein phosphatase corkscrew

2

20

High-throughput

0.713

High

1061444

CAD96
Tyrosine kinase receptor Cad96Ca

1

20

Small-scale

0.713

High

362493

SRC64
Tyrosine-protein kinase Src64B

1

19

High-throughput

0.656

High

1022143

DAB
Protein disabled

3

20

Small-scale

0.655

High

234432

O46034
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.643

High

57046

A1ZAN6
Rho guanine nucleotide exchange factor 2, isoform D

1

19

High-throughput

0.618

High

541192

KRAF1
Raf homolog serine/threonine-protein kinase Raf

1

20

High-throughput

0.618

High

1061417

Q0KHR5
Rho GTPase activating protein at 15B, isoform B

1

20

High-throughput

0.618

High

1061433

ACKL
Activated Cdc42 kinase-like

1

20

High-throughput

0.618

High

1061436

Q9V3C8
DShc protein

1

20

High-throughput

0.618

High

1061449

Q9VDF4
Cortactin, isoform A

1

20

High-throughput

0.618

High

1061455

Q9VHK4
Polychaetoid, isoform B

1

20

High-throughput

0.618

High

1061466

Q9VUH6
Myopic

1

20

High-throughput

0.618

High

1061469

Q9VWB7
LD06925p

1

8

High-throughput

0.618

High

1061471

Q9VWL9
LD25711p

1

20

High-throughput

0.618

High

1061476

ACK
Activated Cdc42 kinase Ack

1

20

Small-scale

0.618

High

583364

DORS
Embryonic polarity protein dorsal

2

7

High-throughput

0.600

High

1061487

Y34F
Uncharacterized protein CG43867

1

20

High-throughput

0.555

High

1061490

X2JFU3
Uncharacterized protein, isoform E

1

20

High-throughput

0.553

High

233514

SPY
Protein sprouty

2

16

High-throughput

0.552

High

1061430

ENA
Protein enabled

1

20

Small-scale

0.515

High

1061447

PFD5
Probable prefoldin subunit 5

1

1

High-throughput

0.508

High

1061483

Q9W3N8
non-specific serine/threonine protein kinase

1

20

High-throughput

0.508

High

1061420

Q7JNX6
Phosphoinositide 3-kinase

1

20

High-throughput

0.492

High

53460

PKN
Serine/threonine-protein kinase N

1

20

High-throughput

0.479

High

68081

A8DY50
Missing-in-metastasis, isoform B

1

12

High-throughput

0.479

High

305035

C3G
Guanine nucleotide-releasing factor 2

1

20

High-throughput

0.479

High

709529

1433Z
14-3-3 protein zeta

1

20

High-throughput

0.479

High

1019846

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

1059286

EXPA
Protein expanded

1

20

High-throughput

0.479

High

1061416

Q0E8H9
beta-N-acetylhexosaminidase

1

3

High-throughput

0.479

High

1061418

Q5U0V7
phosphoinositide 5-phosphatase

1

20

High-throughput

0.479

High

1061424

Q7KV89
Mitogen-activated protein kinase kinase kinase kinase

1

20

High-throughput

0.479

High

1061427

Q8IPP3
Canoe, isoform D

1

20

High-throughput

0.479

High

1061432

LARK
RNA-binding protein lark

1

8

High-throughput

0.479

High

1061442

Q9VB22
LD33695p

1

3

High-throughput

0.479

High

1061446

RGS
Regulator of G-protein signaling loco

1

6

High-throughput

0.479

High

1061451

CYFIP
Cytoplasmic FMR1-interacting protein

1

10

High-throughput

0.479

High

1061452

Q9VFD3
Uncharacterized protein, isoform B

1

20

High-throughput

0.479

High

1061470

Q9VWL0
Mec2

1

4

High-throughput

0.479

High

1061474

AJUBA
LIM domain-containing protein jub

1

20

High-throughput

0.479

High

1061480

DIP2
Disco-interacting protein 2

1

2

High-throughput

0.479

High

1061486

MOODY
G-protein coupled receptor moody

1

18

High-throughput

0.479

High

1061462

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

2

High-throughput

0.464

High

1061463

Q9VTW3
FI06571p

1

15

High-throughput

0.464

High

1061485

Q9W424
Splicing factor 3B subunit 4

1

12

High-throughput

0.464

High

1061440

Q9VA35
CIN85 and CD2AP related, isoform A

1

0

High-throughput

0.458

High

1061473

Q9VX08
LD10434p

1

0

High-throughput

0.458

High

57764

A1ZB77
Uncharacterized protein, isoform J

1

1

High-throughput

0.445

High

121208

ALDR
Aldo-keto reductase 1B

1

3

High-throughput

0.445

High

476929

NDKA
Nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

682730

PROF
Profilin

1

2

High-throughput

0.445

High

855990

MOEH
Moesin/ezrin/radixin homolog 1

1

20

High-throughput

0.445

High

1061423

Q7KTW5
Inositol-1-monophosphatase

1

1

High-throughput

0.445

High

1061426

Q8INK3
Fatty acid-binding protein, muscle

1

2

High-throughput

0.445

High

1061437

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

1

High-throughput

0.445

High

1061450

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

1061459

Q9VPN5
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.445

High

1061482

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.445

High

1061425

Q7KW26
MIP13633p

1

1

High-throughput

0.439

High

549988

NINL
Ninein homolog

1

20

High-throughput

0.437

High

1052386

ATPB
ATP synthase subunit beta, mitochondrial

1

5

High-throughput

0.437

High

1061422

Q7KMK4
BcDNA.GH08789

1

1

High-throughput

0.437

High

1061445

SAV
Scaffold protein salvador

1

20

High-throughput

0.437

High

1061454

Q9VGQ1
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

1061458

Q9VN88
LD45836p

1

3

High-throughput

0.437

High

1061467

Q9VVL7
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.437

High

1061419

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

1061429

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.426

High

1061431

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.426

High

1061434

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.426

High

1061435

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.426

High

1061479

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.426

High

1061489

Q9XZT0
EG:34F3.10 protein

1

1

High-throughput

0.417

High

53393

A1Z7Q5
Uncharacterized protein, isoform A

1

12

High-throughput

0.407

High

53995

A1Z892
1-Cys peroxiredoxin

1

5

High-throughput

0.407

High

197752

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.407

High

1052217

HMGD
High mobility group protein D

1

7

High-throughput

0.407

High

1061421

Q7JVH6
LD24696p

1

3

High-throughput

0.407

High

1061428

Q8MT58
Carnosine dipeptidase 2, isoform A

1

1

High-throughput

0.407

High

1061438

Q9V3V2
peptidylprolyl isomerase

1

7

High-throughput

0.407

High

1061441

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

1061443

Q9VB96
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1061448

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

1061453

Q9VGK3
peptidylprolyl isomerase

1

7

High-throughput

0.407

High

1061456

Q9VHX4
LD24679p

1

3

High-throughput

0.407

High

1061457

Q9VK60
GH25425p

1

1

High-throughput

0.407

High

1061464

Q9VTY2
Uncharacterized protein, isoform A

1

3

High-throughput

0.407

High

1061465

Q9VU35
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.407

High

1061468

Q9VW59
Rho GDP-dissociation inhibitor 3

1

2

High-throughput

0.407

High

1061481

PADC1
PRADC1-like protein

1

4

High-throughput

0.407

High

1061484

Q9W3X6
fumarate hydratase

1

2

High-throughput

0.407

High

1061488

IRS1
Insulin receptor substrate 1

1

13

High-throughput

0.381

High

1061472

Q9VWM7
MIP16618p

2

0

High-throughput

0.310

High

57993

A1ZBC3
Uncharacterized protein

1

0

High-throughput

0.265

Low

1061461

Q9VRQ4
LD47944p

1

0

High-throughput

0.249

Low

1061475

Q9VYR3
LP03706p

1

0

High-throughput

0.249

Low

356330

O97102
Small ubiquitin-related modifier

1

0

High-throughput

0.232

Low

357279

O97428
Ciboulot, isoform A

1

0

High-throughput

0.232

Low

1026625

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

1031172

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.232

Low

1061460

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

1061477

ETIF1
Eukaryotic translation initiation factor eIF1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025