HitPredict

Interactor 1: ERCC3 (P19447)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 782 Hs			1 726
+	Hs
		584546 ERCC3_HUMAN (1-782): 0: 728: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		584606 ERCC3_HUMAN (1-782): 0: 728: 100.00		BRDT_HUMAN (18-695): 2.15e-107: 350: 49.71
+	Hs
		243913 ERCC3_HUMAN (1-782): 0: 728: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		1067163 DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		631608 DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		998944 DDX17_HUMAN (225-769): 2.71e-110: 354: 12.85		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		571417 DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		1271480 DDX17_HUMAN (225-769): 2.71e-110: 354: 12.85		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		134001 DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		999078 DDX47_HUMAN (273-769): 5.98e-101: 321: 13.19		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		244734 DDX17_HUMAN (225-769): 2.71e-110: 354: 12.85		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		243896 DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Sp
		1000065 DRS1_SCHPO (315-782): 2.76e-92: 307: 15.16		YK82_SCHPO (29-148): 6.59e-30: 128: 33.61
+	Hs
		133787 DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		999141 DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		244921 DDX47_HUMAN (273-769): 5.98e-101: 321: 13.19		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		245007 DDX18_HUMAN (189-720): 1.43e-85: 287: 14.88		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56