HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28581483
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 183
+	Hs
		584907 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		584923 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Hs
		584916 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		584910 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2E1_HUMAN (5-173): 1.45e-72: 218: 28.07
+	Hs
		1336390 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D4_HUMAN (30-173): 3.96e-76: 226: 32.19
+	Hs
		849453 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		919870 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Hs
		1297370 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E2_HUMAN (5-173): 1.08e-73: 222: 28.66
+	Hs
		895921 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		1282350 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90
+	Hs
		851889 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E1_HUMAN (5-173): 1.45e-72: 218: 28.07
+	Hs
		895815 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		849406 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		919822 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Hs
		895876 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		851867 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2E1_HUMAN (5-173): 1.45e-72: 218: 28.07
+	Hs
		536760 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		895851 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		536757 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UBE2A_HUMAN (26-172): 2.67e-69: 208: 28.19
+	Hs
		135922 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UBE2C_HUMAN (10-155): 3e-22: 90.1: 34.46