HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	38113892, 16472766
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 183
+	Hs
		584923 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		584907 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		584916 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		584910 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		1336390 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08
+	Hs
		919870 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849453 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895921 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		895815 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		919822 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73
+	Hs
		849406 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		1282350 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00
+	Hs
		1297370 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33
+	Hs
		895876 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		851889 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		536760 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43
+	Hs
		895851 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05
+	Hs
		851867 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33
+	Hs
		536757 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UBE2A_HUMAN (4-150): 8.87e-65: 197: 30.46
+	Hs
		536763 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33