Protein: TRM1
tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)

Gene: TRM1, TRMT1
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q9NXH9

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002940 - tRNA N2-guanine methylation
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

848947

MAGAB
Melanoma-associated antigen 11

5

2

High-throughput

0.725

High

1452033

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.691

High

1313167

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.631

High

1207166

SYAM
Alanine--tRNA ligase, mitochondrial

3

0

High-throughput

0.622

High

1137181

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.618

High

1452030

TRM1
tRNA

1

2

High-throughput

0.618

High

946539

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1392940

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

1452042

HEMK1
MTRF1L release factor glutamine methyltransferase

2

1

High-throughput

0.601

High

1257261

RFPLB
Ret finger protein-like 4B

2

0

High-throughput

0.585

High

243120

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

1067770

EP300
Histone acetyltransferase p300

2

2

High-throughput

0.584

High

1287290

DPP9
Dipeptidyl peptidase 9

2

0

High-throughput

0.576

High

1325847

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

2

0

High-throughput

0.576

High

1335929

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

2

0

High-throughput

0.576

High

1452031

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

0

High-throughput

0.576

High

1452044

LIPG
Endothelial lipase

2

1

High-throughput

0.574

High

928570

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

564451

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

188374

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.513

High

191407

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

274783

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

278767

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

301990

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.513

High

334257

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1037414

H11
Histone H1.1

1

0

High-throughput

0.513

High

1094637

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.513

High

1118616

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.513

High

1143868

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.513

High

1337120

CHDH
Choline dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1437477

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

1452032

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.513

High

1452034

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.513

High

1452035

NOCT
Nocturnin

1

0

High-throughput

0.513

High

1452036

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.513

High

1452045

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.513

High

294426

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

373313

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

533013

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

589864

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

696684

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

769345

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

831533

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

968004

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.479

High

1114455

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1138696

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1141976

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1150705

TRBP2
RISC-loading complex subunit TARBP2

1

3

High-throughput

0.479

High

1155830

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

Small-scale

0.479

High

1255821

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1292817

SKAP1
Src kinase-associated phosphoprotein 1

1

2

High-throughput

0.479

High

1360685

SYNE2
Nesprin-2

1

1

High-throughput

0.479

High

1418473

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1434059

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

155715

CUX2
Homeobox protein cut-like 2

1

0

High-throughput

0.458

High

343649

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.458

High

471287

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519254

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

538011

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

646952

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

786288

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

971186

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1048732

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090571

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1100459

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1140941

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1196330

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

1219898

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.458

High

1364280

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1380671

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1397491

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1419867

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

0

High-throughput

0.458

High

1450449

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1452037

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1452038

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

0

High-throughput

0.458

High

1452040

SHLB1
Endophilin-B1

1

0

High-throughput

0.458

High

1452046

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

651724

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

1

High-throughput

0.445

High

1138900

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

1209728

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1429507

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.445

High

377751

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

1360013

LIPH
Lipase member H

1

1

High-throughput

0.437

High

177611

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.426

High

856409

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.426

High

904392

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.426

High

926130

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.426

High

1110308

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

0

High-throughput

0.426

High

1124070

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.426

High

1244418

BORA
Protein aurora borealis

1

0

High-throughput

0.426

High

1401771

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

1410612

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.426

High

1448496

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.426

High

1452039

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.426

High

1452043

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1204492

RNS10
Inactive ribonuclease-like protein 10

1

0

High-throughput

0.269

Low

562989

SCG2
Secretogranin-2

1

0

High-throughput

0.249

Low

1337599

ARMC2
Armadillo repeat-containing protein 2

1

0

High-throughput

0.249

Low

1397948

MERB1
bMERB domain-containing protein 1

1

0

High-throughput

0.249

Low

1438526

OTOF
Otoferlin

1

0

High-throughput

0.249

Low

1452041

RBGP1
Rab GTPase-activating protein 1

1

0

High-throughput

0.249

Low

1336178

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025