HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 351
+	Hs
		437880 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438502 TRIM6_HUMAN (1-466): 1.7e-130: 388: 43.93		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438654 TRI17_HUMAN (1-471): 6.2e-124: 371: 35.39		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		1162539 TRI17_HUMAN (1-471): 6.2e-124: 371: 35.39		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		432399 TRI17_HUMAN (1-471): 6.2e-124: 371: 35.39		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438501 TRIM7_HUMAN (11-450): 4.66e-121: 365: 34.03		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432238 TRIM7_HUMAN (11-450): 4.66e-121: 365: 34.03		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438587 TRI10_HUMAN (1-453): 6.58e-114: 345: 30.75		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		538271 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		432329 TRI10_HUMAN (1-453): 6.58e-114: 345: 30.75		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		437829 TRI49_HUMAN (7-447): 6.81e-103: 316: 32.29		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431456 TRI49_HUMAN (7-447): 6.81e-103: 316: 32.29		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		62676 TRI64_HUMAN (1-449): 3.78e-119: 358: 34.51		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		438395 TRI41_HUMAN (1-44): 3.5e-10: 64.1: 45.83		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432106 TRI41_HUMAN (1-44): 3.5e-10: 64.1: 45.83		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92