HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25416956, unassigned1304
Identification Methods	validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 184
+	Hs
		584907 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		584923 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		584916 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		584926 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		1336390 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D4_HUMAN (4-157): 1.13e-74: 222: 31.82
+	Hs
		849453 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		919870 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		895921 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		895815 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		849406 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		919822 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		1282350 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E3_HUMAN (3-156): 2.76e-67: 205: 31.17
+	Hs
		1297370 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2E2_HUMAN (3-156): 5.39e-67: 205: 31.17
+	Hs
		895876 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		536760 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		536772 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		895851 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		536757 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		584902 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2R1_HUMAN (37-137): 5.12e-22: 90.9: 42.86
+	Hs
		584914 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2G2_HUMAN (1-137): 1.6e-22: 90.1: 37.16