HitPredict

Interactor 1: E2AK2 (P19525)
Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
Gene: EIF2AK2

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 582
+	Hs
		403081 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		585462 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		585546 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		585572 E2AK2_HUMAN (1-551): 1.25e-165: 483: 100.00		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Rn
		1144336 AKT3_RAT (138-545): 5.64e-121: 366: 20.47		PABP1_RAT (1-405): 6.25e-40: 156: 10.05
+	Mm
		857309 KPCB_MOUSE (75-548): 1.79e-124: 382: 15.77		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Mm
		857306 KPCG_MOUSE (75-548): 1.84e-122: 377: 14.94		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Mm
		554885 KPCE_MOUSE (103-548): 5.63e-120: 372: 18.79		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		984499 KPCD_HUMAN (43-548): 7.52e-133: 403: 15.77		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		566398 KPCA_HUMAN (75-547): 2.61e-127: 389: 16.26		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		969086 KPCE_HUMAN (103-548): 8.91e-120: 371: 19.01		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		681862 AKT1_HUMAN (118-544): 3.32e-122: 369: 20.09		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		403131 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		851480 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		1174853 PLK3_HUMAN (249-534): 1.06e-22: 103: 27.00		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		851506 NEK4_HUMAN (270-534): 1.87e-31: 131: 31.41		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		1162681 PLK3_HUMAN (249-534): 1.06e-22: 103: 27.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23