HitPredict

Interactor 1: CI (P19538)
Transcriptional activator cubitus interruptus (Transcriptional activator ci) (ci form of 155 kDa) (ci-155) (ci full-length protein) (ciFL) [Cleaved into: Transcriptional repressor cubitus interruptus (Transcriptional repressor ci) (ci C-terminally truncated form) (ci form of 75 kDa) (ci-75)]
Gene: CI

Interactor 2: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17925225, 23747190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0035331 - negative regulation of hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1397 Dm			1 774
+	Dm
		585743 CI_DROME (1-1397): 0: 1129: 100.00		Q8IP45_DROME (3-774): 0: 749: 27.50
+	Hs
		485063 GLI2_HUMAN (104-1099): 5.42e-176: 568: 28.48		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		983757 ZNF91_HUMAN (212-996): 5.78e-168: 536: 12.69		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042724 ZN624_HUMAN (322-996): 2.19e-163: 514: 13.19		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041826 Z585A_HUMAN (358-1001): 1.85e-152: 482: 11.99		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041764 ZN658_HUMAN (173-695): 4.97e-148: 479: 13.51		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		67426 ZN850_HUMAN (461-1098): 1.48e-115: 391: 11.55		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042336 ZN300_HUMAN (351-714): 6.89e-113: 370: 22.31		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042045 ZN615_HUMAN (128-602): 5.33e-108: 361: 15.59		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041954 ZN227_HUMAN (438-996): 5.79e-105: 354: 11.50		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041657 ZKSC8_HUMAN (329-676): 4.91e-90: 305: 22.51		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		73014 B4DU56_HUMAN (573-1001): 2.21e-81: 282: 6.62		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042226 ZN566_HUMAN (413-629): 7.64e-82: 277: 29.55		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041578 ZN268_HUMAN (555-1098): 8.09e-76: 274: 8.58		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042053 ZN527_HUMAN (322-575): 2.22e-75: 265: 21.01		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041738 ZN569_HUMAN (637-1098): 1.21e-63: 232: 4.82		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1042314 ZN583_HUMAN (460-676): 2.2e-63: 228: 28.76		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		988832 ZN33B_HUMAN (121-454): 6.86e-61: 226: 7.69		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Hs
		1041696 ZN829_HUMAN (461-676): 1.51e-61: 219: 27.56		CUL3_HUMAN (3-774): 0: 771: 27.45
+	Ce
		712866 TRA1_CAEEL (422-624): 2.5e-55: 213: 55.83		CUL2_CAEEL (8-774): 0: 672: 30.24