HitPredict

Interactor 1: KLK2 (P20151)
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Gene: KLK2

Interactor 2: SPB6 (P35237)
Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)
Gene: SERPINB6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	26186194, 11745444
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 376
+	Hs
		719387 KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65		SPB6_HUMAN (1-376): 1.61e-170: 481: 100.00
+	Hs
		428671 TRY1_HUMAN (2-260): 5.4e-118: 339: 42.09		SPB8_HUMAN (1-376): 1.04e-158: 451: 66.40
+	Hs
		344097 KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90		ANT3_HUMAN (4-376): 1.81e-147: 426: 36.91
+	Mm
		1141519 KLK8_MOUSE (4-257): 1.14e-104: 305: 44.88		SPB6_MOUSE (1-376): 1.92e-161: 459: 75.99
+	Hs
		344274 KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00		AACT_HUMAN (4-376): 1.52e-141: 410: 33.68
+	Hs
		397636 KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00		IPSP_HUMAN (6-376): 1.8e-136: 396: 32.00
+	Mm
		430527 Q9Z1R9_MOUSE (2-260): 8.17e-118: 338: 41.70		A1AT1_MOUSE (4-376): 2.8e-141: 409: 32.36
+	Hs
		344148 KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90		A1AT_HUMAN (2-376): 3.35e-140: 406: 32.01
+	Hs
		714770 TRY3_HUMAN (11-260): 1.71e-111: 324: 42.80		SPB12_HUMAN (1-376): 4.92e-145: 418: 41.24
+	Hs
		344149 KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01		A1AT_HUMAN (2-376): 3.35e-140: 406: 32.01
+	Hs
		397629 KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01		IPSP_HUMAN (6-376): 1.8e-136: 396: 32.00
+	Hs
		344349 KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65		AACT_HUMAN (4-376): 1.52e-141: 410: 33.68
+	Hs
		371463 KLKB1_HUMAN (15-259): 2.13e-92: 286: 33.85		IPSP_HUMAN (6-376): 1.8e-136: 396: 32.00
+	Hs
		344172 CTRL_HUMAN (12-260): 5.28e-92: 273: 34.62		A1AT_HUMAN (2-376): 3.35e-140: 406: 32.01
+	Hs
		198417 KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49		SPB10_HUMAN (1-376): 1.22e-159: 455: 44.84
+	Hs
		344256 KLK4_HUMAN (23-260): 4.68e-52: 171: 40.17		A1AT_HUMAN (2-376): 3.35e-140: 406: 32.01
+	Hs
		198328 KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49		A1AT_HUMAN (2-376): 3.35e-140: 406: 32.01
+	Hs
		421257 KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00		GDN_HUMAN (26-376): 2.23e-58: 196: 32.12
+	Hs
		198377 KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49		CBG_HUMAN (4-376): 2.33e-134: 391: 34.31
+	Hs
		421277 KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65		GDN_HUMAN (26-376): 2.23e-58: 196: 32.12