Protein: SFXN4
Sideroflexin-4 (Breast cancer resistance marker 1)

Gene: SFXN4
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q6P4A7

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006865 - amino acid transport
GO:0015075 - monoatomic ion transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113425

CUL3
Cullin-3

2

3

High-throughput

0.571

High

1162382

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

348569

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.536

High

369356

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.536

High

724690

MK04
Mitogen-activated protein kinase 4

1

2

High-throughput

0.536

High

1242295

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1242296

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.536

High

1242332

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

1242315

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.513

High

1242325

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

412108

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.500

High

85998

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

5

High-throughput

0.489

High

182599

GP182
G-protein coupled receptor 182

1

11

High-throughput

0.489

High

260889

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.489

High

366183

HPT
Haptoglobin

1

1

High-throughput

0.489

High

369470

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.489

High

369688

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.489

High

369880

CO3
Complement C3

1

1

High-throughput

0.489

High

390905

TRFE
Serotransferrin

1

2

High-throughput

0.489

High

391036

TRFL
Lactotransferrin

1

2

High-throughput

0.489

High

723931

LCN1
Lipocalin-1

1

1

High-throughput

0.489

High

749346

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

2

High-throughput

0.489

High

771153

APJ
Apelin receptor

1

7

High-throughput

0.489

High

1009669

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

1034754

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.489

High

1101166

CLN3
Battenin

1

2

High-throughput

0.489

High

1242294

ST32C
Serine/threonine-protein kinase 32C

1

1

High-throughput

0.489

High

1242300

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.489

High

1242322

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

137745

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

2

High-throughput

0.479

High

275041

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

292153

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

High-throughput

0.479

High

588951

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

695737

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

714202

PML
Protein PML

1

5

High-throughput

0.479

High

768456

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

774431

BASI
Basigin

1

6

High-throughput

0.479

High

830935

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

1152432

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.479

High

1163890

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.479

High

1238425

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

1242290

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1242304

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1242306

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

3

High-throughput

0.479

High

1242307

MIC26
MICOS complex subunit MIC26

1

2

High-throughput

0.479

High

1242310

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.479

High

1242311

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

1242314

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

1242319

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1242320

SFXN1
Sideroflexin-1

1

4

High-throughput

0.479

High

1242321

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

1242323

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1242326

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1242327

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

927027

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

959187

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1242293

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

Small-scale

0.458

High

1242301

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1055061

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

1

High-throughput

0.457

High

943972

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1209289

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1242329

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

2

Small-scale

0.445

High

293867

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

970668

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1242286

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1242287

BAKOR
Beclin 1-associated autophagy-related key regulator

1

3

High-throughput

0.437

High

1242289

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1242291

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.437

High

1242292

MOB3B
MOB kinase activator 3B

1

1

High-throughput

0.437

High

1242305

BROMI
Protein broad-minded

1

1

Small-scale

0.437

High

1242309

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1242316

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

1242317

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1242324

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.437

High

1242331

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.437

High

379108

IGKC
Immunoglobulin kappa constant

1

7

High-throughput

0.407

High

379261

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.407

High

379363

IGHG2
Immunoglobulin heavy constant gamma 2

1

6

High-throughput

0.407

High

379531

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.407

High

379661

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

High-throughput

0.407

High

379747

IGHA2
Immunoglobulin heavy constant alpha 2

1

6

High-throughput

0.407

High

1226890

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

1242298

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1242288

TBA1A
Tubulin alpha-1A chain

2

0

High-throughput

0.298

High

61115

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.279

Low

286554

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

361539

CERU
Ceruloplasmin

1

0

High-throughput

0.279

Low

378695

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

379005

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

387281

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.279

Low

389661

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.279

Low

389838

TTHY
Transthyretin

1

0

High-throughput

0.279

Low

391144

HEMO
Hemopexin

1

0

High-throughput

0.279

Low

626054

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

0

High-throughput

0.279

Low

627891

TCO1
Transcobalamin-1

1

0

High-throughput

0.279

Low

1242285

LEG1H
Protein LEG1 homolog

1

0

High-throughput

0.279

Low

1242302

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

1242313

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1242318

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1242328

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

0

High-throughput

0.279

Low

777708

VGFR3
Vascular endothelial growth factor receptor 3

1

0

High-throughput

0.261

Low

319847

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

488810

FURIN
Furin

1

0

High-throughput

0.249

Low

693003

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.249

Low

1135711

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1242297

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.249

Low

1242299

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1242303

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1242312

MTMRC
Myotubularin-related protein 12

1

0

High-throughput

0.249

Low

1242330

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

0

High-throughput

0.249

Low

1242308

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025