HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 36736316, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 292
+	Hs
		590125 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		590162 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		414732 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		590149 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Hs
		625350 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Mm
		851183 CCNA2_MOUSE (4-432): 3.17e-135: 396: 85.12		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Mm
		509476 CCNA2_MOUSE (4-432): 3.17e-135: 396: 85.12		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Mm
		956329 CCNA1_MOUSE (10-432): 2.81e-130: 383: 46.15		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Hs
		414855 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		538471 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		538521 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	At
		621660 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		1104377 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD1_ARATH (2-292): 1.36e-129: 375: 49.14
+	At
		1104376 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD2_ARATH (1-292): 2.99e-129: 372: 46.58
+	Hs
		414711 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	At
		1104379 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	At
		1103349 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	Hs
		538497 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	At
		1104370 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		639339 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98