HitPredict

Interactor 1: BTF3 (P20290)
Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)
Gene: BTF3

Interactor 2: NACA2 (Q9H009)
Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like)
Gene: NACA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	NAC~NAC
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005854 - nascent polypeptide-associated complex GO:0015031 - protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 206 Hs			1 215
+	Hs
		590906 BTF3_HUMAN (1-206): 3.5e-94: 275: 100.00		NACA_HUMAN (1-215): 2.5e-86: 255: 90.23
+	Hs
		166496 BTF3_HUMAN (1-206): 3.5e-94: 275: 100.00		NACAD_HUMAN (4-215): 4.04e-71: 236: 57.53
+	Hs
		1295755 BT3L4_HUMAN (50-206): 5.07e-67: 204: 81.01		NACA2_HUMAN (1-215): 1.51e-92: 271: 100.00
+	Hs
		1045198 BT3L4_HUMAN (50-206): 5.07e-67: 204: 81.01		NACA_HUMAN (1-215): 2.5e-86: 255: 90.23
+	Hs
		166511 BT3L4_HUMAN (50-206): 5.07e-67: 204: 81.01		NACAD_HUMAN (4-215): 4.04e-71: 236: 57.53
+	Dm
		1180829 Q7KM15_DROME (50-201): 3.3e-57: 179: 63.40		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Ce
		1090365 BTF3_CAEEL (53-204): 4.88e-59: 184: 63.16		NACA_CAEEL (20-215): 1.01e-62: 195: 50.51
+	Dm
		1180836 Q7KM15_DROME (50-201): 3.3e-57: 179: 63.40		Q9VPV7_DROME (6-215): 4.99e-62: 198: 35.50
+	Dm
		1276591 Q9VPR2_DROME (50-205): 6.66e-44: 157: 59.87		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Dm
		1372034 Q9VPR2_DROME (50-205): 6.66e-44: 157: 59.87		Q9VPV7_DROME (6-215): 4.99e-62: 198: 35.50
+	Dm
		1276606 Q9VY34_DROME (50-136): 4.56e-27: 105: 35.63		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Dm
		71736 B3DNI1_DROME (50-136): 1.25e-26: 104: 36.78		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Dm
		1001359 Q0IGS9_DROME (50-136): 2.9e-26: 103: 34.48		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Dm
		1276607 Q9VY63_DROME (50-136): 3.25e-26: 103: 36.78		NACA_DROME (6-215): 2.2e-69: 213: 55.19
+	Pf
		86939 Q8ILK2_PLAF7 (47-203): 3.43e-41: 139: 32.93		C6KT55_PLAF7 (63-214): 6.2e-56: 177: 34.42
+	Dm
		1372155 Q9VY34_DROME (50-136): 4.56e-27: 105: 35.63		Q9VPV7_DROME (6-215): 4.99e-62: 198: 35.50
+	Dm
		71738 B3DNI1_DROME (50-136): 1.25e-26: 104: 36.78		Q9VPV7_DROME (6-215): 4.99e-62: 198: 35.50
+	Dm
		1001360 Q0IGS9_DROME (50-136): 2.9e-26: 103: 34.48		Q9VPV7_DROME (6-215): 4.99e-62: 198: 35.50
+	Sc
		756709 NACB1_YEAST (50-199): 3.71e-48: 156: 36.13		NACA_YEAST (62-214): 6.69e-43: 144: 31.95
+	Sc
		756680 NACB2_YEAST (50-172): 2.41e-43: 144: 34.92		NACA_YEAST (62-214): 6.69e-43: 144: 31.95