Protein: KPCB
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)

Gene: KPCB, PRKCB
Organism: Homo sapiens
Interactions: 211
UniProt ID: P05771

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

436576

KPCB
Protein kinase C beta type

6

16

Small-scale

0.934

High

436615

AKT1
RAC-alpha serine/threonine-protein kinase

4

17

Small-scale

0.888

High

436603

KPCA
Protein kinase C alpha type

3

17

High-throughput

0.871

High

436611

ARBK1
Beta-adrenergic receptor kinase 1

2

19

Small-scale

0.834

High

436599

NCF1
Neutrophil cytosol factor 1

3

11

Small-scale

0.827

High

436662

KPCD
Protein kinase C delta type

2

16

High-throughput

0.811

High

436699

GRP3
Ras guanyl-releasing protein 3

2

8

Small-scale

0.778

High

193486

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

19

Small-scale

0.768

High

436582

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.754

High

171988

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

2

11

High-throughput

0.737

High

290288

KS6A4
Ribosomal protein S6 kinase alpha-4

2

17

High-throughput

0.737

High

436588

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

15

High-throughput

0.737

High

436589

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

15

High-throughput

0.737

High

436593

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

10

High-throughput

0.737

High

436627

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

7

High-throughput

0.737

High

436647

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

6

High-throughput

0.737

High

436657

SRSF2
Serine/arginine-rich splicing factor 2

2

5

High-throughput

0.737

High

436669

ZN638
Zinc finger protein 638

2

3

High-throughput

0.737

High

436677

CDC37
Hsp90 co-chaperone Cdc37

2

8

High-throughput

0.737

High

436683

CARL1
F-actin-uncapping protein LRRC16A

2

7

High-throughput

0.737

High

436718

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

4

High-throughput

0.737

High

436723

SH3G3
Endophilin-A3

2

6

High-throughput

0.737

High

436734

OSBL8
Oxysterol-binding protein-related protein 8

2

2

High-throughput

0.737

High

436752

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

15

High-throughput

0.737

High

436753

ABCF2
ATP-binding cassette sub-family F member 2

2

1

High-throughput

0.737

High

436736

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

7

Small-scale

0.724

High

436748

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

Small-scale

0.724

High

247209

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

15

Small-scale

0.715

High

436648

RACK1
Small ribosomal subunit protein RACK1

4

13

Small-scale

0.702

High

163031

CHK1
Serine/threonine-protein kinase Chk1

2

0

High-throughput

0.699

High

424619

KPCG
Protein kinase C gamma type

1

17

High-throughput

0.691

High

436733

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

4

4

Small-scale

0.680

High

436690

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

12

Small-scale

0.665

High

436757

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

5

High-throughput

0.665

High

436703

SRBD1
S1 RNA-binding domain-containing protein 1

2

1

High-throughput

0.659

High

388892

FINC
Fibronectin

1

0

High-throughput

0.656

High

362589

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.647

High

436626

RGS2
Regulator of G-protein signaling 2

1

3

Small-scale

0.647

High

436633

GSK3A
Glycogen synthase kinase-3 alpha

1

19

Small-scale

0.647

High

436663

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.647

High

436666

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

Small-scale

0.647

High

436702

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

436638

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

9

Small-scale

0.646

High

436704

SHCBP
SHC SH2 domain-binding protein 1

2

1

High-throughput

0.621

High

436592

TAU
Microtubule-associated protein tau

2

13

Small-scale

0.619

High

240489

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.618

High

436578

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.618

High

436581

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

436583

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

436597

NCAM1
Neural cell adhesion molecule 1

1

2

Small-scale

0.618

High

436598

DRD2
D(2) dopamine receptor

1

3

Small-scale

0.618

High

436622

DRD3
D(3) dopamine receptor

1

2

Small-scale

0.618

High

436623

PPM1A
Protein phosphatase 1A

1

1

Small-scale

0.618

High

436641

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

436649

ACTS
Actin, alpha skeletal muscle

1

9

Small-scale

0.618

High

436676

PKN1
Serine/threonine-protein kinase N1

1

16

Small-scale

0.618

High

436737

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.618

High

436681

SYT6
Synaptotagmin-6

1

0

Small-scale

0.614

High

436608

LMNB1
Lamin-B1

2

13

Small-scale

0.595

High

436616

ARRB2
Beta-arrestin-2

2

5

Small-scale

0.584

High

436646

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

4

Small-scale

0.584

High

436655

CLH1
Clathrin heavy chain 1

2

3

Small-scale

0.584

High

436656

MDM2
E3 ubiquitin-protein ligase Mdm2

2

4

Small-scale

0.584

High

436707

TRI41
E3 ubiquitin-protein ligase TRIM41

1

8

Small-scale

0.578

High

436732

CAR11
Caspase recruitment domain-containing protein 11

1

13

Small-scale

0.578

High

256737

H2B1K
Histone H2B type 1-K

2

20

High-throughput

0.571

High

346805

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.571

High

415271

HSPB1
Heat shock protein beta-1

2

13

High-throughput

0.571

High

418778

H2A1B
Histone H2A type 1-B/E

2

10

High-throughput

0.571

High

436579

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.571

High

436586

H2AZ
Histone H2A.Z

2

12

High-throughput

0.571

High

436587

H2A1
Histone H2A type 1

2

10

High-throughput

0.571

High

436591

H14
Histone H1.4

2

18

High-throughput

0.571

High

436596

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

1

High-throughput

0.571

High

436600

H2AX
Histone H2AX

2

10

High-throughput

0.571

High

436602

H12
Histone H1.2

2

18

High-throughput

0.571

High

436607

H2A1D
Histone H2A type 1-D

2

10

High-throughput

0.571

High

436609

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

2

High-throughput

0.571

High

436612

HMGB2
High mobility group protein B2

2

12

High-throughput

0.571

High

436613

DPOD1
DNA polymerase delta catalytic subunit

2

1

High-throughput

0.571

High

436619

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.571

High

436624

ARL2
ADP-ribosylation factor-like protein 2

2

4

High-throughput

0.571

High

436628

RL27A
Large ribosomal subunit protein uL15

2

1

High-throughput

0.571

High

436629

COPD
Coatomer subunit delta

2

1

High-throughput

0.571

High

436635

MOT1
Monocarboxylate transporter 1

2

1

High-throughput

0.571

High

436637

H2BFS
Histone H2B type F-S

2

20

High-throughput

0.571

High

436639

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.571

High

436643

ERF1
Eukaryotic peptide chain release factor subunit 1

2

2

High-throughput

0.571

High

436644

H4
Histone H4

2

2

High-throughput

0.571

High

436650

TBA4A
Tubulin alpha-4A chain

2

9

High-throughput

0.571

High

436659

AKA12
A-kinase anchor protein 12

2

4

High-throughput

0.571

High

436661

UBXN1
UBX domain-containing protein 1

2

1

High-throughput

0.571

High

436668

LBR
Delta(14)-sterol reductase LBR

2

2

High-throughput

0.571

High

436670

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

6

High-throughput

0.571

High

436674

PCH2
Pachytene checkpoint protein 2 homolog

2

14

High-throughput

0.571

High

436675

MLF2
Myeloid leukemia factor 2

2

1

High-throughput

0.571

High

436678

H2A2C
Histone H2A type 2-C

2

10

High-throughput

0.571

High

436679

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.571

High

436680

EMAL3
Echinoderm microtubule-associated protein-like 3

2

3

High-throughput

0.571

High

436686

H2A2A
Histone H2A type 2-A

2

10

High-throughput

0.571

High

436691

H32
Histone H3.2

2

7

High-throughput

0.571

High

436692

H2AV
Histone H2A.V

2

12

High-throughput

0.571

High

436693

DDX46
Probable ATP-dependent RNA helicase DDX46

2

3

High-throughput

0.571

High

436694

H2A3
Histone H2A type 3

2

10

High-throughput

0.571

High

436695

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

13

High-throughput

0.571

High

436697

DDX42
ATP-dependent RNA helicase DDX42

2

3

High-throughput

0.571

High

436700

CCAR1
Cell division cycle and apoptosis regulator protein 1

2

6

High-throughput

0.571

High

436701

CCAR2
Cell cycle and apoptosis regulator protein 2

2

1

High-throughput

0.571

High

436705

RHPN1
Rhophilin-1

2

7

High-throughput

0.571

High

436706

GEMI5
Gem-associated protein 5

2

7

High-throughput

0.571

High

436711

H2A1C
Histone H2A type 1-C

2

10

High-throughput

0.571

High

436716

H2A1H
Histone H2A type 1-H

2

10

High-throughput

0.571

High

436719

H2B1N
Histone H2B type 1-N

2

20

High-throughput

0.571

High

436720

H2A1J
Histone H2A type 1-J

2

10

High-throughput

0.571

High

436721

H2B1M
Histone H2B type 1-M

2

20

High-throughput

0.571

High

436722

H2B1L
Histone H2B type 1-L

2

20

High-throughput

0.571

High

436724

GDF15
Growth/differentiation factor 15

2

1

High-throughput

0.571

High

436725

DDX50
ATP-dependent RNA helicase DDX50

2

4

High-throughput

0.571

High

436726

PELO
Protein pelota homolog

2

2

High-throughput

0.571

High

436729

H2AJ
Histone H2A.J

2

10

High-throughput

0.571

High

436738

DHX33
ATP-dependent RNA helicase DHX33

2

2

High-throughput

0.571

High

436740

PDLI7
PDZ and LIM domain protein 7

2

15

High-throughput

0.571

High

436741

DDX21
Nucleolar RNA helicase 2

2

4

High-throughput

0.571

High

436743

DDX18
ATP-dependent RNA helicase DDX18

2

3

High-throughput

0.571

High

436747

TECR
Very-long-chain enoyl-CoA reductase

2

1

High-throughput

0.571

High

436751

DIC
Mitochondrial dicarboxylate carrier

2

14

High-throughput

0.571

High

436755

ACSL5
Long-chain-fatty-acid--CoA ligase 5

2

1

High-throughput

0.571

High

249406

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

Small-scale

0.561

High

345035

RIGI
Antiviral innate immune response receptor RIG-I

1

8

Small-scale

0.561

High

436621

HSP74
Heat shock 70 kDa protein 4

1

15

Small-scale

0.561

High

436714

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

Small-scale

0.561

High

436715

PDLI5
PDZ and LIM domain protein 5

1

16

Small-scale

0.552

High

436651

H31
Histone H3.1

1

7

Small-scale

0.550

High

436727

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.549

High

221504

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

0

High-throughput

0.547

High

338274

SC24A
Protein transport protein Sec24A

2

0

High-throughput

0.547

High

436584

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

2

0

High-throughput

0.547

High

436594

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

2

0

High-throughput

0.547

High

436606

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

0

High-throughput

0.547

High

436640

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.547

High

436696

ZC3C1
Zinc finger C3HC-type protein 1

2

0

High-throughput

0.547

High

436709

NDRG1
Protein NDRG1

2

0

High-throughput

0.547

High

436717

PURB
Transcriptional regulator protein Pur-beta

2

0

High-throughput

0.547

High

436728

SEN34
tRNA-splicing endonuclease subunit Sen34

2

0

High-throughput

0.547

High

436730

TBCD
Tubulin-specific chaperone D

2

0

High-throughput

0.547

High

436735

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

2

0

High-throughput

0.547

High

436742

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

0

High-throughput

0.547

High

436745

HPF1
Histone PARylation factor 1

2

0

High-throughput

0.547

High

436754

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

2

0

High-throughput

0.547

High

436759

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

2

0

High-throughput

0.547

High

436634

BIEA
Biliverdin reductase A

1

3

Small-scale

0.536

High

436761

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.536

High

246395

KDM1A
Lysine-specific histone demethylase 1A

1

2

Small-scale

0.536

High

436739

RDH14
Retinol dehydrogenase 14

1

2

High-throughput

0.536

High

436636

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

436652

RT05
Small ribosomal subunit protein uS5m

2

1

High-throughput

0.521

High

436688

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

2

2

High-throughput

0.521

High

436708

AP3S1
AP-3 complex subunit sigma-1

2

2

High-throughput

0.521

High

436750

DHCR7
7-dehydrocholesterol reductase

2

2

High-throughput

0.521

High

436605

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

8

Small-scale

0.515

High

436685

ADAL
N6-Methyl-AMP deaminase

1

1

High-throughput

0.515

High

436689

LIAT1
Protein LIAT1

1

1

High-throughput

0.515

High

331621

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.513

High

436713

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

388033

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

424050

ITB2
Integrin beta-2

1

15

Small-scale

0.501

High

436577

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.501

High

436595

TOP2A
DNA topoisomerase 2-alpha

1

6

Small-scale

0.501

High

436601

H15
Histone H1.5

1

18

Small-scale

0.501

High

436604

DNLI1
DNA ligase 1

1

1

Small-scale

0.501

High

436614

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

Small-scale

0.501

High

436620

SDC2
Syndecan-2

1

4

Small-scale

0.501

High

436625

CASR
Extracellular calcium-sensing receptor

1

8

Small-scale

0.501

High

436630

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

8

Small-scale

0.501

High

436632

NUMB
Protein numb homolog

1

11

Small-scale

0.501

High

436642

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

Small-scale

0.501

High

436654

DAB2
Disabled homolog 2

1

12

Small-scale

0.501

High

436658

H11
Histone H1.1

1

18

Small-scale

0.501

High

436660

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

8

Small-scale

0.501

High

436665

EP300
Histone acetyltransferase p300

1

9

Small-scale

0.501

High

436667

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

8

Small-scale

0.501

High

436673

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.501

High

436756

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

5

Small-scale

0.501

High

436760

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

436682

MTCL3
Microtubule cross-linking factor 3

1

15

High-throughput

0.489

High

436580

H10
Histone H1.0

1

0

Small-scale

0.480

High

423991

ITB3
Integrin beta-3

1

13

Small-scale

0.479

High

436590

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

436610

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

5

Small-scale

0.479

High

436617

IL3RB
Cytokine receptor common subunit beta

1

5

Small-scale

0.479

High

436631

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

436671

EEA1
Early endosome antigen 1

1

6

High-throughput

0.479

High

436672

PDK1
[Pyruvate dehydrogenase

1

3

Small-scale

0.479

High

436684

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

436687

RICTR
Rapamycin-insensitive companion of mTOR

1

4

Small-scale

0.479

High

436710

REQU
Zinc finger protein ubi-d4

1

4

High-throughput

0.479

High

436618

LSP1
Lymphocyte-specific protein 1

1

0

Small-scale

0.458

High

436744

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

Small-scale

0.458

High

436664

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

436645

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.445

High

105124

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

254264

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.298

High

436585

COX6C
Cytochrome c oxidase subunit 6C

2

0

High-throughput

0.298

High

436653

RT06
Small ribosomal subunit protein bS6m

2

0

High-throughput

0.298

High

436698

DOPP1
Dolichyldiphosphatase 1

2

0

High-throughput

0.298

High

436712

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

2

0

High-throughput

0.298

High

436731

DERL1
Derlin-1

2

0

High-throughput

0.298

High

436746

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

High-throughput

0.298

High

436758

MAN1
Inner nuclear membrane protein Man1

2

0

High-throughput

0.298

High

436749

DEC1
Deleted in esophageal cancer 1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025