HitPredict

Interactor 1: RAB4A (P20338)
Ras-related protein Rab-4A (EC 3.6.5.2)
Gene: RAB4A

Interactor 2: RABX5 (Q9UJ41)
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Gene: RABGEF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~VPS9
Common GO terms	GO:0015031 - protein transport GO:0031901 - early endosome membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 491
+	Hs
		914438 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		RABX5_HUMAN (1-491): 0: 563: 100.00
+	Dm
		1197048 Q86BK8_DROME (3-218): 6.99e-93: 273: 56.94		Q9W0H9_DROME (1-470): 4.91e-143: 428: 33.27
+	Hs
		591982 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		ANR27_HUMAN (123-435): 9.66e-78: 264: 18.83
+	Hs
		895196 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Mm
		1160701 RAB4B_MOUSE (6-218): 6.08e-83: 247: 86.85		GAPD1_MOUSE (45-372): 6.83e-74: 256: 20.48
+	Hs
		1137131 Q5U0I6_HUMAN (3-218): 3.01e-85: 252: 38.43		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		72912 B4DMN1_HUMAN (2-217): 2.21e-84: 252: 42.13		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		918912 RAB1A_HUMAN (3-218): 3.01e-85: 252: 38.43		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10
+	Hs
		895011 RAB4B_HUMAN (6-218): 4.89e-83: 247: 87.32		RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10