Protein: MSH3
DNA mismatch repair protein MSH3 (Mismatch-binding protein) (MBP) (MutS protein homolog 3)

Gene: MSH3
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P25336

Gene Ontology (top 5):
GO:0000406 - double-strand/single-strand DNA junction binding
GO:0000710 - meiotic mismatch repair
GO:0000735 - removal of nonhomologous ends
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

672000

MSH2
DNA mismatch repair protein MSH2

10

12

Small-scale

0.975

High

672029

MSH6
DNA mismatch repair protein MSH6

3

12

Small-scale

0.855

High

571272

PMS1
DNA mismatch repair protein PMS1

2

20

Small-scale

0.778

High

672012

MLH1
DNA mismatch repair protein MLH1

2

20

Small-scale

0.778

High

672031

MLH2
DNA mismatch repair protein MLH2

1

20

Small-scale

0.647

High

578906

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.646

High

672013

SAW1
Single-strand annealing weakened protein 1

2

1

Small-scale

0.629

High

586430

PCNA
Proliferating cell nuclear antigen

3

9

Small-scale

0.623

High

672003

HS104
Heat shock protein 104

2

2

High-throughput

0.584

High

672028

LGE1
Transcriptional regulatory protein LGE1

2

2

High-throughput

0.571

High

449279

RAD10
DNA repair protein RAD10

1

2

Small-scale

0.561

High

672033

SLX4
Structure-specific endonuclease subunit SLX4

1

1

Small-scale

0.552

High

525998

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

672016

SSB2
Ribosome-associated molecular chaperone SSB2

2

13

High-throughput

0.552

High

380982

H2B1
Histone H2B.1

1

9

High-throughput

0.536

High

647704

RFA1
Replication factor A protein 1

1

5

High-throughput

0.536

High

672001

RFA3
Replication factor A protein 3

1

1

High-throughput

0.536

High

671998

PEX34
Peroxisomal membrane protein PEX34

1

0

High-throughput

0.518

High

448360

RAD1
DNA repair protein RAD1

1

2

Small-scale

0.501

High

598816

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.500

High

671999

CDC48
Cell division control protein 48

1

2

High-throughput

0.500

High

672018

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

Small-scale

0.489

High

672025

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.481

High

432292

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439096

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.479

High

572521

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

672005

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

672007

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

3

High-throughput

0.479

High

672017

MPH1
ATP-dependent DNA helicase MPH1

1

3

High-throughput

0.479

High

672032

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

672035

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

672037

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.479

High

366641

ARGI
Arginase

1

0

High-throughput

0.458

High

576045

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

0

High-throughput

0.458

High

672002

MLS1
Malate synthase 1

1

0

High-throughput

0.458

High

672010

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

672021

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

672022

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

672023

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

672027

UBC7
Ubiquitin-conjugating enzyme E2 7

1

4

High-throughput

0.457

High

364941

KPYK1
Pyruvate kinase 1

1

3

High-throughput

0.445

High

394268

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

481497

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

543916

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.445

High

592035

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

627831

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

1

High-throughput

0.445

High

672019

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

672036

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.445

High

360950

CCPR
Cytochrome c peroxidase, mitochondrial

1

1

High-throughput

0.437

High

672004

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

2

High-throughput

0.437

High

672034

RDL1
Thiosulfate:glutathione sulfurtransferase

1

1

High-throughput

0.437

High

427148

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

432499

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.426

High

453438

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

672011

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

672015

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.426

High

672020

GCN20
Protein GCN20

1

0

High-throughput

0.426

High

672026

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.426

High

672030

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.426

High

672006

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.407

High

672024

BIOA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

1

0

High-throughput

0.279

Low

405037

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

672008

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

672009

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

672014

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

575391

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025