Protein: MSH6
DNA mismatch repair protein MSH6 (MutS protein homolog 6) (Postmeiotic segregation protein 3)

Gene: MSH6
Organism: Saccharomyces cerevisiae S288C
Interactions: 67
UniProt ID: Q03834

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000710 - meiotic mismatch repair
GO:0003676 - nucleic acid binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

682938

MSH2
DNA mismatch repair protein MSH2

33

13

Small-scale

0.993

High

807644

MLH1
DNA mismatch repair protein MLH1

5

20

Small-scale

0.919

High

571282

PMS1
DNA mismatch repair protein PMS1

5

20

Small-scale

0.917

High

672029

MSH3
DNA mismatch repair protein MSH3

3

12

Small-scale

0.855

High

586482

PCNA
Proliferating cell nuclear antigen

11

9

Small-scale

0.757

High

647828

RFA1
Replication factor A protein 1

3

5

Small-scale

0.662

High

826397

MPH1
ATP-dependent DNA helicase MPH1

3

3

High-throughput

0.662

High

1044190

CMR1
DNA damage-binding protein CMR1

3

5

High-throughput

0.662

High

763291

SGS1
ATP-dependent helicase SGS1

3

7

Small-scale

0.650

High

1044186

MLH2
DNA mismatch repair protein MLH2

1

20

Small-scale

0.647

High

560245

TOP3
DNA topoisomerase 3

3

1

High-throughput

0.643

High

744770

MG101
Mitochondrial genome maintenance protein MGM101

3

1

Small-scale

0.643

High

448469

RAD52
DNA repair and recombination protein RAD52

2

2

High-throughput

0.621

High

639061

VPS1
Vacuolar protein sorting-associated protein 1

2

1

High-throughput

0.621

High

724889

RAD16
DNA repair protein RAD16

2

10

High-throughput

0.621

High

793451

ATR
Serine/threonine-protein kinase MEC1

2

6

High-throughput

0.621

High

546124

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.601

High

1044184

LCD1
DNA damage checkpoint protein LCD1

2

0

High-throughput

0.595

High

850567

RSC8
Chromatin structure-remodeling complex protein RSC8

2

1

High-throughput

0.588

High

1044188

RUVB2
RuvB-like protein 2

2

1

High-throughput

0.588

High

594548

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

High-throughput

0.584

High

393263

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.575

High

579997

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.575

High

925023

APJ1
J domain-containing protein APJ1

2

5

High-throughput

0.571

High

1038819

LGE1
Transcriptional regulatory protein LGE1

2

2

High-throughput

0.571

High

688764

RFA2
Replication factor A protein 2

2

5

High-throughput

0.567

High

688816

RFA3
Replication factor A protein 3

2

1

High-throughput

0.567

High

736591

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

2

2

High-throughput

0.567

High

364722

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.561

High

554764

REV1
DNA repair protein REV1

1

4

Small-scale

0.561

High

527577

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

819682

SSB2
Ribosome-associated molecular chaperone SSB2

2

13

High-throughput

0.552

High

709960

BMH1
Protein BMH1

1

2

High-throughput

0.500

High

835816

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

Small-scale

0.489

High

381619

H2B2
Histone H2B.2

1

9

High-throughput

0.479

High

382312

H4
Histone H4

1

2

High-throughput

0.479

High

708068

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

735139

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

814741

EXO1
Exodeoxyribonuclease 1

1

6

High-throughput

0.479

High

963693

H3
Histone H3

1

10

High-throughput

0.479

High

1044182

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

1044187

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

800676

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.458

High

805839

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

849891

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

394868

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

592476

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

676303

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

727290

HS104
Heat shock protein 104

1

2

High-throughput

0.445

High

736720

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.445

High

742313

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

752682

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

781796

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

804422

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

811489

XDJ1
DnaJ protein homolog XDJ1

1

5

High-throughput

0.445

High

836876

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

871558

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.445

High

1044183

YHP1
Homeobox protein YHP1

1

1

High-throughput

0.445

High

1044189

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.445

High

531872

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

863717

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

858394

STU2
Protein STU2

1

1

High-throughput

0.407

High

1044185

SHS1
Seventh homolog of septin 1

2

0

High-throughput

0.307

High

932815

SLG1
Protein SLG1

1

0

Small-scale

0.288

High

779881

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

672264

CDC10
Cell division control protein 10

1

0

High-throughput

0.249

Low

739755

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025