HitPredict

Interactor 1: RAB4A (P20338)
Ras-related protein Rab-4A (EC 3.6.5.2)
Gene: RAB4A

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 37232246
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015031 - protein transport GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 1785
+	Hs
		914498 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		895339 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		592090 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		914499 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Sc
		502989 YPT31_YEAST (1-184): 1.2e-54: 175: 47.28		SEC7_YEAST (206-1767): 0: 1155: 27.89
+	Sc
		350838 YPT1_YEAST (6-184): 3.71e-54: 174: 48.05		SEC7_YEAST (206-1767): 0: 1155: 27.89
+	Sc
		503016 YPT32_YEAST (1-190): 3.81e-52: 169: 45.26		SEC7_YEAST (206-1767): 0: 1155: 27.89
+	Hs
		895298 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		914406 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Sc
		350883 YPT1_YEAST (6-184): 3.71e-54: 174: 48.05		GEA2_YEAST (41-1121): 2.58e-173: 567: 16.55
+	Sc
		350894 YPT1_YEAST (6-184): 3.71e-54: 174: 48.05		GEA1_YEAST (106-1114): 4.16e-154: 512: 16.36
+	Hs
		895210 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		914254 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		895121 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88
+	Hs
		591905 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		914170 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61