HitPredict

Interactor 1: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Interactor 2: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 9233798, 10644995
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PK_Tyr_Ser-Thr, SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005102 - signaling receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007162 - negative regulation of cell adhesion
GO:0048013 - ephrin receptor signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1047
Hs

1 1055
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Last updated: 15 Jul 2024