HitPredict

Interactor 1: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22057045
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1047 Hs			1 913
+	Hs
		522768 RASA1_HUMAN (1-1047): 0: 824: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		507850 RASA1_HUMAN (1-1047): 0: 824: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		433252 RASA1_HUMAN (1-1047): 0: 824: 100.00		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Hs
		384251 RASA1_HUMAN (1-1047): 0: 824: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		411293 RASA1_HUMAN (1-1047): 0: 824: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435533 RASA1_HUMAN (1-1047): 0: 824: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Mm
		93302 E9PYG6_MOUSE (1-1047): 0: 823: 95.03		ABL1_MOUSE (604-903): 6.09e-49: 190: 37.67
+	Hs
		508255 NGAP_HUMAN (492-1040): 9.8e-115: 383: 24.83		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		522851 IQGA1_HUMAN (394-1044): 2.98e-94: 331: 12.78		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		1083877 SYGP1_HUMAN (375-1030): 6.69e-106: 362: 19.45		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Mm
		100010 SYGP1_MOUSE (375-1030): 3.98e-106: 363: 19.45		NTRK3_MOUSE (604-905): 7.1e-104: 343: 43.05
+	Hs
		384986 DAB2P_HUMAN (491-1046): 1.09e-126: 417: 25.62		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		609394 IQGA3_HUMAN (401-1044): 1.11e-77: 281: 12.22		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		384460 IQGA1_HUMAN (394-1044): 2.98e-94: 331: 12.78		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		385102 IQGA3_HUMAN (401-1044): 1.11e-77: 281: 12.22		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Rn
		783507 PTN11_RAT (168-347): 1.18e-25: 115: 24.63		NTRK2_RAT (604-906): 6.67e-105: 345: 43.89
+	Hs
		384697 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Rn
		783510 PTN11_RAT (168-347): 1.18e-25: 115: 24.63		T2CB11_RAT (600-908): 1.72e-51: 199: 36.25
+	Hs
		411363 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435620 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22