HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34581821, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 396
+	Hs
		598260 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBXW7_HUMAN (128-395): 4.9e-60: 208: 13.76
+	Hs
		598268 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SNR40_HUMAN (140-394): 5.23e-55: 186: 13.41
+	Hs
		598040 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44
+	Hs
		598209 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5B_HUMAN (220-396): 1.61e-42: 153: 18.99
+	Hs
		597996 FLNA_HUMAN (1-2647): 0: 2776: 100.00		LIS1_HUMAN (218-395): 1.1e-38: 145: 14.44
+	Hs
		598240 FLNA_HUMAN (1-2647): 0: 2776: 100.00		POC1B_HUMAN (228-395): 1.45e-33: 132: 15.29
+	Hs
		261236 FLNB_HUMAN (28-2647): 0: 2710: 69.63		WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44
+	Hs
		598083 FLNA_HUMAN (1-2647): 0: 2776: 100.00		RBBP4_HUMAN (32-173): 1.68e-17: 85.6: 18.07
+	Hs
		598345 FLNA_HUMAN (1-2647): 0: 2776: 100.00		NLE1_HUMAN (3-71): 4.91e-16: 81.3: 18.57
+	Hs
		598140 FLNA_HUMAN (1-2647): 0: 2776: 100.00		RBBP7_HUMAN (129-368): 4.26e-15: 78.3: 19.22
+	Hs
		598352 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WSB2_HUMAN (98-272): 5.13e-11: 65.9: 28.81
+	Hs
		598398 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WSB1_HUMAN (59-272): 1.44e-10: 64.3: 27.98
+	Hs
		903137 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44
+	Hs
		957555 PGBM_HUMAN (181-1251): 3.53e-32: 140: 12.81		FBXW7_HUMAN (128-395): 4.9e-60: 208: 13.76
+	Hs
		957556 PGBM_HUMAN (181-1251): 3.53e-32: 140: 12.81		SNR40_HUMAN (140-394): 5.23e-55: 186: 13.41