HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: RHG24 (Q8N264)
Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
Gene: ARHGAP24

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.626

Property	Details
Experiments	21926999, 16862148
Identification Methods	anti tag coimmunoprecipitation, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 748
+	Hs
		598161 FLNA_HUMAN (1-2647): 0: 2776: 100.00		RHG21_HUMAN (52-746): 1.92e-93: 322: 16.62
+	Hs
		598176 FLNA_HUMAN (1-2647): 0: 2776: 100.00		RHGBA_HUMAN (118-743): 1.06e-67: 243: 15.11
+	Hs
		261167 FLNB_HUMAN (28-2647): 0: 2710: 69.63		FA13A_HUMAN (110-676): 4.57e-69: 247: 19.97
+	Hs
		521574 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		RHG24_HUMAN (1-748): 0: 637: 100.00
+	Hs
		211612 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		RHG24_HUMAN (1-748): 0: 637: 100.00
+	Ce
		711279 Q9XVU8_CAEEL (22-349): 7.09e-114: 388: 24.48		PAC1_CAEEL (90-720): 4.93e-71: 255: 16.25
+	Ce
		711275 Q23158_CAEEL (23-268): 6.21e-105: 362: 32.93		PAC1_CAEEL (90-720): 4.93e-71: 255: 16.25