HitPredict

Interactor 1: FGFR2 (P21803)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Keratinocyte growth factor receptor) (KGFR) (CD antigen CD332)
Gene: FGFR2

Interactor 2: CRKL (P47941)
Crk-like protein
Gene: CRKL

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19307307
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0009887 - animal organ morphogenesis GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Mm			1 303
+	Hs
		507902 FGFR1_HUMAN (1-820): 0: 765: 70.45		CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70
+	Mm
		555262 FGFR1_MOUSE (1-820): 0: 761: 69.72		CRKL_MOUSE (1-303): 2.83e-76: 236: 100.00
+	Hs
		580923 FGFR2_HUMAN (1-821): 0: 850: 96.96		PLCG1_HUMAN (3-202): 1.58e-29: 120: 19.44
+	Hs
		507901 FGFR1_HUMAN (1-820): 0: 765: 70.45		CRK_HUMAN (3-302): 1.68e-60: 196: 54.57
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 850: 96.96		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		601605 FGFR2_HUMAN (1-821): 0: 850: 96.96		ITSN2_HUMAN (86-190): 3.43e-10: 62.8: 20.00
+	Hs
		507843 FGFR1_HUMAN (1-820): 0: 765: 70.45		PLCG1_HUMAN (3-202): 1.58e-29: 120: 19.44
+	Hs
		507835 FGFR1_HUMAN (1-820): 0: 765: 70.45		PLCG2_HUMAN (3-188): 3.83e-29: 119: 18.91
+	Hs
		507939 FGFR1_HUMAN (1-820): 0: 765: 70.45		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Rn
		499160 FGFR1_RAT (1-813): 0: 753: 70.00		PLCG1_RAT (3-202): 3.45e-30: 122: 18.52
+	Hs
		208983 FGFR1_HUMAN (1-820): 0: 765: 70.45		NCK2_HUMAN (13-98): 1.08e-18: 87.4: 31.03
+	Hs
		507829 FGFR1_HUMAN (1-820): 0: 765: 70.45		VAV_HUMAN (213-293): 6.43e-17: 83.2: 30.49
+	Hs
		508140 FGFR1_HUMAN (1-820): 0: 765: 70.45		SH3K1_HUMAN (198-297): 3.86e-16: 80.5: 23.53
+	Hs
		507832 FGFR1_HUMAN (1-820): 0: 765: 70.45		NCK1_HUMAN (85-211): 8.85e-15: 75.7: 20.61
+	Hs
		508233 FGFR1_HUMAN (1-820): 0: 765: 70.45		ITSN2_HUMAN (86-190): 3.43e-10: 62.8: 20.00
+	Hs
		665378 EPHA3_HUMAN (8-778): 0: 619: 19.72		CRK_HUMAN (3-302): 1.68e-60: 196: 54.57
+	Mm
		1144837 Q8BRB1_MOUSE (8-778): 0: 611: 19.98		CRK_MOUSE (3-302): 1.23e-60: 196: 54.57
+	Hs
		872610 EPHB1_HUMAN (3-794): 0: 622: 17.81		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		665389 EPHA3_HUMAN (8-778): 0: 619: 19.72		GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28
+	Hs
		557644 EPHB1_HUMAN (3-794): 0: 622: 17.81		NCK1_HUMAN (85-211): 8.85e-15: 75.7: 20.61