HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: MATK (P42679)
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)
Gene: MATK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 507
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (30-493): 0: 523: 34.52
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (4-494): 0: 519: 32.03
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (26-490): 3.62e-178: 512: 33.47
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (45-485): 8.23e-174: 498: 53.05
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (13-503): 2.01e-164: 498: 31.37
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (14-490): 4.73e-171: 493: 31.73
+	Hs
		601907 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ITK_HUMAN (33-484): 4.01e-169: 493: 33.12
+	Hs
		601856 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLK_HUMAN (10-492): 2.69e-169: 489: 32.66
+	Hs
		601836 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TXK_HUMAN (1-484): 1.5e-154: 452: 29.47
+	Hs
		601835 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TEC_HUMAN (16-490): 3.23e-152: 450: 29.41
+	Hs
		412202 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FYN_HUMAN (28-493): 0: 527: 32.23
+	Hs
		433359 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		411729 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Hs
		561380 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FER_HUMAN (75-478): 2.04e-80: 268: 38.86
+	Hs
		337480 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		601919 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTK6_HUMAN (66-479): 8.11e-80: 258: 38.73
+	Hs
		433770 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LYN_HUMAN (14-490): 4.73e-171: 493: 31.73