HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	22261253
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 156
+	Hs
		60297 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		POTEF_HUMAN (1-130): 1.26e-29: 115: 19.55
+	Hs
		601939 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		POTEE_HUMAN (49-152): 2.11e-18: 82.7: 14.82
+	Hs
		602024 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		383675 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		338292 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		338353 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		383676 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21
+	Hs
		339124 EGFR_HUMAN (18-1157): 0: 1041: 42.30		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		339062 EGFR_HUMAN (18-1157): 0: 1041: 42.30		RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21
+	Hs
		790752 ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Mm
		222869 ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75		ANK2_MOUSE (3-155): 1.8e-37: 137: 17.37
+	Hs
		434183 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		435574 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		665163 EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		665164 EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		337406 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		665581 EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		665591 EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		665165 EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40		CDN2C_HUMAN (21-135): 1.37e-25: 97.4: 28.21
+	Hs
		665360 EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48