Protein: TRI58
E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)

Gene: TRI58, TRIM58
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q8NG06

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding
GO:0010468 - regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1339803

TRI58
E3 ubiquitin-protein ligase TRIM58

1

16

Small-scale

0.647

High

141577

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.618

High

156645

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

2

Small-scale

0.578

High

1027599

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.553

High

252361

TLR2
Toll-like receptor 2

1

3

Small-scale

0.552

High

957138

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.501

High

1177171

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.481

High

1040854

MECOM
Histone-lysine N-methyltransferase MECOM

1

20

High-throughput

0.481

High

566424

K2C5
Keratin, type II cytoskeletal 5

1

5

Small-scale

0.479

High

573176

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

764894

CTNB1
Catenin beta-1

1

6

Small-scale

0.479

High

790068

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.479

High

952965

ACTB
Actin, cytoplasmic 1

1

10

Small-scale

0.479

High

1016527

SRSF3
Serine/arginine-rich splicing factor 3

1

5

Small-scale

0.479

High

1123983

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

1259366

TBA1A
Tubulin alpha-1A chain

1

8

Small-scale

0.479

High

1339804

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

1

Small-scale

0.479

High

210590

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

Small-scale

0.458

High

911010

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.445

High

991639

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.445

High

1204711

TAF7L
Transcription initiation factor TFIID subunit 7-like

1

1

High-throughput

0.445

High

1239884

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.445

High

1323204

PDK1L
Serine/threonine-protein kinase PDIK1L

1

7

High-throughput

0.445

High

1339808

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.445

High

1250738

MPRIP
Myosin phosphatase Rho-interacting protein

1

9

Small-scale

0.437

High

1339811

TMOD3
Tropomodulin-3

1

5

Small-scale

0.437

High

1339807

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.426

High

615572

NELFE
Negative elongation factor E

1

1

High-throughput

0.407

High

896587

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.407

High

1063453

GOGA2
Golgin subfamily A member 2

1

8

High-throughput

0.407

High

1150455

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

2

High-throughput

0.407

High

1196888

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

1

High-throughput

0.407

High

1292169

LIPB1
Liprin-beta-1

1

7

High-throughput

0.407

High

1339812

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.407

High

601776

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.249

Low

207756

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

High-throughput

0.232

Low

346770

CER1
Cerberus

1

0

High-throughput

0.232

Low

1339805

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.232

Low

1339806

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.232

Low

1339809

HMCES
Abasic site processing protein HMCES

1

0

High-throughput

0.232

Low

1339810

SOST
Sclerostin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025