HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: S10AA (P60903)
Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)
Gene: S100A10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	24189400, 31980649, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, ubiquitin reconstruction, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 97
+	Hs
		601812 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		S10A4_HUMAN (1-87): 5.03e-29: 101: 35.56
+	Hs
		380734 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		S100B_HUMAN (3-87): 2.3e-26: 94.6: 37.50
+	Hs
		893799 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10AA_HUMAN (1-97): 2.01e-38: 125: 100.00
+	Hs
		685170 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10AB_HUMAN (2-89): 4.9e-32: 109: 38.46
+	Hs
		642945 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10A4_HUMAN (1-87): 5.03e-29: 101: 35.56
+	Hs
		383643 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AB_HUMAN (2-89): 4.9e-32: 109: 38.46
+	Hs
		338220 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10AA_HUMAN (1-97): 2.01e-38: 125: 100.00
+	Hs
		383930 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AG_HUMAN (3-96): 6.44e-26: 93.8: 23.47
+	Hs
		338660 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HORN_HUMAN (1-97): 6.55e-32: 118: 30.69
+	Hs
		338011 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10AB_HUMAN (2-89): 4.9e-32: 109: 38.46
+	Hs
		383989 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AE_HUMAN (3-81): 4.74e-19: 76.5: 28.40
+	Hs
		337773 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A9_HUMAN (3-96): 8.76e-29: 101: 29.59
+	Hs
		337962 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A4_HUMAN (1-87): 5.03e-29: 101: 35.56
+	Hs
		338001 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A7_HUMAN (3-96): 1.13e-20: 80.7: 21.88
+	Hs
		416337 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		S10A9_HUMAN (3-96): 8.76e-29: 101: 29.59
+	Hs
		396674 INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51		S10A8_HUMAN (1-93): 1.69e-23: 87.6: 25.00