HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: RIN1 (Q13671)
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
Gene: RIN1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	31980649, 16273093, unassigned2173
Identification Methods	two hybrid, unspecified method, ubiquitin reconstruction, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 783
+	Hs
		383793 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		RIN1_HUMAN (1-783): 0: 734: 100.00
+	Hs
		383902 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		RIN2_HUMAN (50-705): 0: 578: 29.43
+	Hs
		601935 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Hs
		601934 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		602002 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS1_HUMAN (10-225): 3.96e-37: 152: 16.46
+	Hs
		601945 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS4_HUMAN (2-214): 1.14e-35: 146: 17.67
+	Hs
		601998 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SLAP2_HUMAN (19-170): 5.44e-26: 109: 18.64
+	Hs
		1070975 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Hs
		1070974 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		1071015 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS1_HUMAN (10-225): 3.96e-37: 152: 16.46
+	Hs
		1070981 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS4_HUMAN (2-214): 1.14e-35: 146: 17.67
+	Hs
		181866 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32
+	Hs
		1071013 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		SLAP2_HUMAN (19-170): 5.44e-26: 109: 18.64
+	Hs
		383853 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS3_HUMAN (28-227): 4.82e-43: 171: 20.37
+	Rn
		94037 Q9QX70_RAT (24-1145): 0: 1054: 43.41		F1LN91_RAT (28-227): 2.13e-43: 172: 18.98
+	Hs
		383851 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS2_HUMAN (4-230): 1.01e-38: 157: 18.60
+	Hs
		383987 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS1_HUMAN (10-225): 3.96e-37: 152: 16.46
+	Hs
		181758 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32
+	Hs
		383977 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		SLAP2_HUMAN (19-170): 5.44e-26: 109: 18.64
+	Hs
		181754 EGFR_HUMAN (18-1157): 0: 1041: 42.30		SOCS1_HUMAN (49-192): 1.35e-26: 110: 24.32