HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: MTMR8 (Q96EF0)
Myotubularin-related protein 8 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Gene: MTMR8

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 704
+	Hs
		602030 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MTMR6_HUMAN (1-543): 0: 744: 61.28
+	Hs
		601915 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MTMR2_HUMAN (2-541): 0: 732: 37.89
+	Hs
		338827 EGFR_HUMAN (18-1157): 0: 1041: 42.30		MTMR8_HUMAN (1-704): 0: 1076: 100.00
+	Hs
		601914 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MTMR1_HUMAN (2-542): 0: 725: 37.16
+	Hs
		601982 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MTMR9_HUMAN (2-539): 0: 665: 34.38
+	Hs
		1071029 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		MTMR6_HUMAN (1-543): 0: 744: 61.28
+	Hs
		1040904 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		MTMR2_HUMAN (2-541): 0: 732: 37.89
+	Hs
		602013 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MTMRA_HUMAN (9-553): 3.52e-160: 483: 21.99
+	Hs
		1071002 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		MTMR9_HUMAN (2-539): 0: 665: 34.38
+	Hs
		339156 EGFR_HUMAN (18-1157): 0: 1041: 42.30		MTMR6_HUMAN (1-543): 0: 744: 61.28
+	Hs
		338864 EGFR_HUMAN (18-1157): 0: 1041: 42.30		MTMR9_HUMAN (2-539): 0: 665: 34.38
+	Hs
		59909 EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13		MTMRB_HUMAN (17-493): 9.38e-118: 370: 20.90