Protein: SORL
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)

Gene: SORL, SORL1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q92673

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001540 - amyloid-beta binding
GO:0002024 - diet induced thermogenesis
GO:0004888 - transmembrane signaling receptor activity
GO:0005041 - low-density lipoprotein particle receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720518

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

11

Small-scale

0.949

High

422759

A4
Amyloid-beta precursor protein

5

16

Small-scale

0.934

High

1366653

SORL
Sortilin-related receptor

4

15

Small-scale

0.907

High

170261

AURKA
Aurora kinase A

4

1

High-throughput

0.895

High

627551

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

3

High-throughput

0.861

High

1308072

EGFL6
Epidermal growth factor-like protein 6

2

11

High-throughput

0.811

High

1151805

RHOH
Rho-related GTP-binding protein RhoH

2

20

High-throughput

0.783

High

689990

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

10

Small-scale

0.761

High

543433

PSG1
Pregnancy-specific beta-1-glycoprotein 1

2

5

High-throughput

0.726

High

1366669

ZN408
Zinc finger protein 408

2

10

High-throughput

0.726

High

477108

IL6RA
Interleukin-6 receptor subunit alpha

1

12

Small-scale

0.724

High

1366685

GGA1
ADP-ribosylation factor-binding protein GGA1

5

8

Small-scale

0.720

High

1355963

NET5
Netrin-5

2

8

High-throughput

0.694

High

469819

CATG
Cathepsin G

1

13

High-throughput

0.691

High

567936

PRG2
Bone marrow proteoglycan

1

9

High-throughput

0.691

High

571199

HGF
Hepatocyte growth factor

1

14

High-throughput

0.691

High

663564

CMA1
Chymase

1

17

High-throughput

0.691

High

1115867

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.691

High

1363117

CLC2B
C-type lectin domain family 2 member B

1

9

High-throughput

0.691

High

1366663

GDF15
Growth/differentiation factor 15

1

2

High-throughput

0.691

High

1366664

SOST
Sclerostin

1

5

High-throughput

0.691

High

1366666

BSSP4
Brain-specific serine protease 4

1

8

High-throughput

0.691

High

1366667

SIRPD
Signal-regulatory protein delta

1

3

High-throughput

0.691

High

1366679

DKK2
Dickkopf-related protein 2

1

8

High-throughput

0.691

High

1366682

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.691

High

1366674

FBX6
F-box only protein 6

4

10

High-throughput

0.683

High

282854

CRLF1
Cytokine receptor-like factor 1

1

12

Small-scale

0.681

High

426988

IL6
Interleukin-6

1

1

Small-scale

0.681

High

1366684

GGA2
ADP-ribosylation factor-binding protein GGA2

3

8

Small-scale

0.674

High

125551

LEG9
Galectin-9

3

11

High-throughput

0.667

High

127382

LEG8
Galectin-8

3

11

High-throughput

0.667

High

1187779

SP6
Transcription factor Sp6

3

11

High-throughput

0.667

High

227175

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

10

High-throughput

0.665

High

410975

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.647

High

641643

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.647

High

1366661

SORT
Sortilin

1

4

Small-scale

0.647

High

814922

GDNF
Glial cell line-derived neurotrophic factor

1

0

Small-scale

0.646

High

335665

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

1

High-throughput

0.628

High

787884

SRBP1
Sterol regulatory element-binding protein 1

2

4

High-throughput

0.628

High

1105529

OS9
Protein OS-9

2

1

High-throughput

0.628

High

1279013

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.628

High

416637

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.618

High

1248777

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.618

High

1324475

AN36B
Ankyrin repeat domain-containing protein 36B

1

10

High-throughput

0.618

High

1065012

FGL1
Fibrinogen-like protein 1

1

4

High-throughput

0.618

High

1366678

CLCF1
Cardiotrophin-like cytokine factor 1

1

2

Small-scale

0.618

High

1366690

DUS10
Dual specificity protein phosphatase 10

1

3

High-throughput

0.618

High

335364

CCN6
Cellular communication network factor 6

2

4

High-throughput

0.611

High

1331460

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

480869

LEG1
Galectin-1

2

11

High-throughput

0.601

High

1366686

FBX2
F-box only protein 2

2

10

High-throughput

0.601

High

387446

APOE
Apolipoprotein E

2

7

Small-scale

0.595

High

1366681

EGFL7
Epidermal growth factor-like protein 7

1

12

High-throughput

0.575

High

70902

ZBBX
Zinc finger B-box domain-containing protein 1

2

1

High-throughput

0.574

High

212813

ZN264
Zinc finger protein 264

2

2

High-throughput

0.574

High

1133380

ZN169
Zinc finger protein 169

2

3

High-throughput

0.574

High

1234700

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.574

High

1252054

ZN517
Zinc finger protein 517

2

17

High-throughput

0.574

High

1294605

Z354C
Zinc finger protein 354C

2

10

High-throughput

0.574

High

1346579

ZN563
Zinc finger protein 563

2

3

High-throughput

0.574

High

1366673

ZN331
Zinc finger protein 331

2

7

High-throughput

0.574

High

1366677

ZN224
Zinc finger protein 224

2

4

High-throughput

0.574

High

1351102

SP7
Transcription factor Sp7

2

8

High-throughput

0.565

High

1243289

ZN549
Zinc finger protein 549

2

1

High-throughput

0.558

High

484607

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

2

High-throughput

0.558

High

1007968

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

1254886

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

1360139

PATE1
Prostate and testis expressed protein 1

2

3

High-throughput

0.549

High

49571

FEZF1
Fez family zinc finger protein 1

1

13

High-throughput

0.536

High

224507

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.536

High

231055

VEGFD
Vascular endothelial growth factor D

1

3

High-throughput

0.536

High

351716

SG1D1
Secretoglobin family 1D member 1

1

3

High-throughput

0.536

High

483679

WNT2
Protein Wnt-2

1

16

High-throughput

0.536

High

506885

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

564148

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

570702

EDN3
Endothelin-3

1

3

High-throughput

0.536

High

626972

FST
Follistatin

1

4

High-throughput

0.536

High

634948

MIME
Mimecan

1

8

High-throughput

0.536

High

698967

CALX
Calnexin

1

9

High-throughput

0.536

High

774786

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.536

High

871173

TFPI2
Tissue factor pathway inhibitor 2

1

15

High-throughput

0.536

High

933205

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

1025939

NDP
Norrin

1

2

High-throughput

0.536

High

1093898

TRAF1
TNF receptor-associated factor 1

1

2

High-throughput

0.536

High

1112633

CUL1
Cullin-1

1

12

High-throughput

0.536

High

1132165

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.536

High

1249677

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.536

High

1315906

ZNF34
Zinc finger protein 34

1

10

High-throughput

0.536

High

1325169

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.536

High

1350023

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

1366654

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1366659

TAFA4
Chemokine-like protein TAFA-4

1

8

High-throughput

0.536

High

1366668

GREM2
Gremlin-2

1

2

High-throughput

0.536

High

1366671

CDHR5
Cadherin-related family member 5

1

8

High-throughput

0.536

High

1366672

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

1366675

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.536

High

1366676

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

212982

HS12A
Heat shock 70 kDa protein 12A

1

0

Small-scale

0.529

High

1247323

BRWD3
Bromodomain and WD repeat-containing protein 3

1

0

High-throughput

0.517

High

851194

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.515

High

1366655

KAT5
Histone acetyltransferase KAT5

1

3

High-throughput

0.515

High

837375

ASIP
Agouti-signaling protein

1

0

High-throughput

0.513

High

992283

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1272508

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

939868

GFRA1
GDNF family receptor alpha-1

1

0

Small-scale

0.505

High

361809

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.493

High

627687

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.493

High

517796

GLI4
Zinc finger protein GLI4

1

11

High-throughput

0.489

High

600470

ZNF26
Zinc finger protein 26

1

2

High-throughput

0.489

High

640607

MK
Midkine

1

4

High-throughput

0.489

High

1081803

ZN816
Zinc finger protein 816

1

2

High-throughput

0.489

High

1159268

ZNF74
Zinc finger protein 74

1

9

High-throughput

0.489

High

1160428

TAZ
Tafazzin

1

4

High-throughput

0.489

High

1180726

ZN284
Zinc finger protein 284

1

4

High-throughput

0.489

High

1187848

FX4L6
Forkhead box protein D4-like 6

1

7

High-throughput

0.489

High

1253575

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.489

High

1308547

ZN584
Zinc finger protein 584

1

11

High-throughput

0.489

High

1329155

DB123
Beta-defensin 123

1

3

High-throughput

0.489

High

1330849

ZN713
Zinc finger protein 713

1

15

High-throughput

0.489

High

1335615

ZN485
Zinc finger protein 485

1

10

High-throughput

0.489

High

1366657

ZN707
Zinc finger protein 707

1

19

High-throughput

0.489

High

1366665

SCRT1
Transcriptional repressor scratch 1

1

14

High-throughput

0.489

High

1366683

SALL4
Sal-like protein 4

1

3

High-throughput

0.489

High

1366687

ZN777
Zinc finger protein 777

1

10

High-throughput

0.489

High

1366689

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

10

High-throughput

0.489

High

967888

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.486

High

218570

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

458708

SAP
Prosaposin

1

1

High-throughput

0.479

High

693882

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

723711

NEUT
Neurotensin/neuromedin N [Cleaved into: Large neuromedin N

1

1

Small-scale

0.479

High

1113886

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1179076

RSPO1
R-spondin-1

1

6

High-throughput

0.479

High

1246205

APOA5
Apolipoprotein A-V

1

7

Small-scale

0.479

High

1309468

CEP97
Centrosomal protein of 97 kDa

1

2

High-throughput

0.479

High

1366656

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1366680

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1014173

CBX1
Chromobox protein homolog 1

1

1

High-throughput

0.470

High

959016

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1250564

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

Small-scale

0.458

High

1366662

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

167459

WNT9A
Protein Wnt-9a

1

16

High-throughput

0.445

High

170904

CLGN
Calmegin

1

9

High-throughput

0.445

High

1230832

SL9A4
Sodium/hydrogen exchanger 4

1

6

High-throughput

0.445

High

1359292

SSMM1
Serine-rich single-pass membrane protein 1

1

1

High-throughput

0.445

High

1366660

FRMD6
FERM domain-containing protein 6

1

1

High-throughput

0.445

High

106379

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

1219457

SLX4I
Protein SLX4IP

1

1

Small-scale

0.437

High

1366670

SP110
Sp110 nuclear body protein

1

5

High-throughput

0.437

High

1329614

CD177
CD177 antigen

1

0

Small-scale

0.426

High

517321

GOG8G
Golgin subfamily A member 8G

1

4

High-throughput

0.407

High

584128

FOSL2
Fos-related antigen 2

3

0

High-throughput

0.347

High

1205078

FA76B
Protein FAM76B

2

0

High-throughput

0.318

High

725168

HXC12
Homeobox protein Hox-C12

1

0

High-throughput

0.279

Low

1366688

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

622230

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1322173

Q8N0S8
VPS29 protein

1

0

High-throughput

0.268

Low

1366658

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

1135757

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025