HitPredict

Interactor 1: KDPD (P21865)
Sensor protein KdpD (EC 2.7.13.3)
Gene: KDPD

Interactor 2: KDPE (P21866)
KDP operon transcriptional regulatory protein KdpE
Gene: KDPE

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	24561554, 15522865, 19400808
Identification Methods	two hybrid, affinity chromatography technology, phosphotransferase assay, adenylate cyclase complementation, two hybrid array
Interaction Type	direct interaction, phosphotransfer reaction, physical association

Property	Details
Interacting Pfam domains	HATPase_c~Response_reg, HisKA~Response_reg
Common GO terms	GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Ec			1 225
+	Mt
		958577 KDPD_MYCTU (10-889): 0: 717: 31.33		KDPE_MYCTU (1-224): 3.62e-71: 218: 49.33
+	Mx
		1091479 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1DCL7_MYXXD (4-224): 2.01e-75: 229: 42.86
+	Mx
		1091414 Q1D0A1_MYXXD (349-881): 5.18e-71: 245: 18.86		Q1D1K9_MYXXD (3-224): 3.1e-71: 218: 35.14
+	Mx
		1091420 Q1D0A1_MYXXD (349-881): 5.18e-71: 245: 18.86		Q1D8M8_MYXXD (4-225): 4.24e-69: 213: 37.05
+	Mx
		1091444 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1D1K9_MYXXD (3-224): 3.1e-71: 218: 35.14
+	Mx
		1091248 Q1CVV2_MYXXD (437-894): 7.8e-65: 235: 21.62		Q1D1K9_MYXXD (3-224): 3.1e-71: 218: 35.14
+	Mx
		1091475 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1D8M8_MYXXD (4-225): 4.24e-69: 213: 37.05
+	Mx
		1091418 Q1D0A1_MYXXD (349-881): 5.18e-71: 245: 18.86		Q1D6S6_MYXXD (2-225): 1.79e-66: 206: 34.67
+	Mx
		1091469 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1D334_MYXXD (1-223): 5.74e-68: 210: 36.28
+	Mx
		1091500 Q1D8M1_MYXXD (601-884): 2.09e-63: 234: 30.00		Q1D4T4_MYXXD (2-225): 3.12e-70: 216: 34.78
+	Mx
		1091472 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1D6S6_MYXXD (2-225): 1.79e-66: 206: 34.67
+	Mx
		1091541 Q1D8M1_MYXXD (601-884): 2.09e-63: 234: 30.00		Q1D6S6_MYXXD (2-225): 1.79e-66: 206: 34.67
+	Af
		577530 VIRA_AGRFC (468-880): 2.07e-64: 234: 19.34		Q7CXM1_AGRFC (3-225): 1.95e-66: 206: 33.48
+	Mx
		1091398 Q1D8M1_MYXXD (601-884): 2.09e-63: 234: 30.00		Q1CZP3_MYXXD (3-224): 2.7e-66: 205: 33.63
+	Ss
		1122361 Q55941_SYNY3 (462-885): 1.54e-65: 228: 13.96		Q55942_SYNY3 (2-223): 1.17e-67: 209: 30.97
+	Mx
		1091371 Q1D333_MYXXD (462-890): 7.67e-70: 240: 21.04		Q1CYI6_MYXXD (4-225): 1.03e-61: 194: 34.67
+	Mx
		1091422 Q1D0A1_MYXXD (349-881): 5.18e-71: 245: 18.86		Q1DBP1_MYXXD (2-223): 1.77e-58: 185: 31.25
+	Af
		428851 VIRA_AGRFC (468-880): 2.07e-64: 234: 19.34		VIRG_AGRFC (1-223): 1.02e-61: 195: 34.80
+	Mx
		1091315 Q1CWW4_MYXXD (600-881): 2.6e-62: 227: 27.34		Q1CYI6_MYXXD (4-225): 1.03e-61: 194: 34.67
+	Ss
		937876 Q55783_SYNY3 (507-884): 2.72e-68: 235: 22.34		P73104_SYNY3 (3-216): 5.1e-55: 176: 23.96