Protein: EP15R
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)

Gene: EP15R, EPS15L1
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q9UBC2

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1360380

STON2
Stonin-2

3

15

Small-scale

0.854

High

1154186

ITSN1
Intersectin-1

9

19

High-throughput

0.752

High

1453438

ITSN2
Intersectin-2

5

18

High-throughput

0.713

High

1386728

AP2M1
AP-2 complex subunit mu

4

15

High-throughput

0.699

High

922619

AP2S1
AP-2 complex subunit sigma

4

13

High-throughput

0.697

High

164123

NDC80
Kinetochore protein NDC80 homolog

4

16

High-throughput

0.689

High

989151

AP2B1
AP-2 complex subunit beta

3

20

High-throughput

0.667

High

1438393

SPC25
Kinetochore protein Spc25

3

1

High-throughput

0.667

High

1453528

SPN90
NCK-interacting protein with SH3 domain

3

2

High-throughput

0.662

High

535623

BIP
Endoplasmic reticulum chaperone BiP

3

10

High-throughput

0.650

High

839840

EPS15
Epidermal growth factor receptor substrate 15

2

16

High-throughput

0.628

High

920329

PLK1
Serine/threonine-protein kinase PLK1

2

7

High-throughput

0.628

High

1293306

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.628

High

155700

FCHO1
F-BAR domain only protein 1

2

20

Small-scale

0.619

High

1070518

FCHO2
F-BAR domain only protein 2

2

19

Small-scale

0.619

High

1410831

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

2

15

Small-scale

0.619

High

515658

TPC2A
Trafficking protein particle complex subunit 2

2

2

High-throughput

0.611

High

508761

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

13

High-throughput

0.602

High

1033438

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.602

High

1145416

RNPS1
RNA-binding protein with serine-rich domain 1

2

4

High-throughput

0.601

High

106785

APRIO
Alternative prion protein

3

5

High-throughput

0.585

High

159900

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

9

Small-scale

0.584

High

1202506

RUN3A
RUN domain-containing protein 3A

2

6

High-throughput

0.574

High

992456

GBG5

1

1

High-throughput

0.573

High

1367481

ESR2
Estrogen receptor beta

2

15

High-throughput

0.571

High

1458288

UBQL1
Ubiquilin-1

1

10

Small-scale

0.552

High

170399

AURKA
Aurora kinase A

1

6

High-throughput

0.536

High

272765

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

9

High-throughput

0.536

High

323797

AP2A2
AP-2 complex subunit alpha-2

1

20

High-throughput

0.536

High

344818

AP2A1
AP-2 complex subunit alpha-1

1

20

High-throughput

0.536

High

964762

DCAF7
DDB1- and CUL4-associated factor 7

1

6

High-throughput

0.536

High

987997

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.536

High

1083331

AP1B1
AP-1 complex subunit beta-1

1

20

High-throughput

0.536

High

1091041

BFSP1
Filensin

1

20

High-throughput

0.536

High

1115623

ASPP2
Apoptosis-stimulating of p53 protein 2

1

6

High-throughput

0.536

High

1116090

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.536

High

1216691

CROCC
Rootletin

1

14

High-throughput

0.536

High

1288388

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.536

High

1337708

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.536

High

1347885

RIN3
Ras and Rab interactor 3

1

11

High-throughput

0.536

High

1398387

CEP63
Centrosomal protein of 63 kDa

1

16

High-throughput

0.536

High

1415821

KIFC1
Kinesin-like protein KIFC1

1

3

High-throughput

0.536

High

1417981

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.536

High

1435527

GARE1
GRB2-associated and regulator of MAPK protein 1

1

3

High-throughput

0.536

High

1450993

NECP2
Adaptin ear-binding coat-associated protein 2

1

5

High-throughput

0.536

High

1290503

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

7

High-throughput

0.515

High

1458293

HYOU1
Hypoxia up-regulated protein 1

1

6

High-throughput

0.515

High

178662

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

1180915

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

1

0

High-throughput

0.513

High

1258729

ZN365
Protein ZNF365

1

0

High-throughput

0.513

High

362393

ABL1
Tyrosine-protein kinase ABL1

1

16

High-throughput

0.501

High

1122915

SIM2
Single-minded homolog 2

1

4

High-throughput

0.494

High

1179873

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1308140

LUR1L
Leucine rich adaptor protein 1-like

1

6

High-throughput

0.489

High

1322154

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.489

High

1348984

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

515739

TPC2B
Trafficking protein particle complex subunit 2B

1

2

High-throughput

0.481

High

1399279

LRRC7
Leucine-rich repeat-containing protein 7

1

1

High-throughput

0.481

High

1380053

CAVN3
Caveolae-associated protein 3

1

0

Small-scale

0.479

High

173494

XPO1
Exportin-1

1

4

High-throughput

0.479

High

210614

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

1

High-throughput

0.479

High

218902

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

226244

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

244025

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

6

High-throughput

0.479

High

247454

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

3

High-throughput

0.479

High

412741

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

483242

CLCA
Clathrin light chain A

1

9

High-throughput

0.479

High

538045

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

556392

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

643116

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.479

High

651448

CBL
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.479

High

714482

PML
Protein PML

1

10

High-throughput

0.479

High

720348

UFO
Tyrosine-protein kinase receptor UFO

1

13

Small-scale

0.479

High

755809

MCM4
DNA replication licensing factor MCM4

1

6

High-throughput

0.479

High

783440

TRI23
E3 ubiquitin-protein ligase TRIM23

1

5

High-throughput

0.479

High

862510

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

888366

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

976630

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.479

High

1026574

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1031577

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1057477

SOX4
Transcription factor SOX-4

1

2

High-throughput

0.479

High

1060698

SOS1
Son of sevenless homolog 1

1

11

High-throughput

0.479

High

1091468

ANK3
Ankyrin-3

1

13

High-throughput

0.479

High

1128301

MCM6
DNA replication licensing factor MCM6

1

6

High-throughput

0.479

High

1130208

SMC1A
Structural maintenance of chromosomes protein 1A

1

4

High-throughput

0.479

High

1135477

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

9

High-throughput

0.479

High

1140978

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1227621

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

1255918

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1276353

ATG9A
Autophagy-related protein 9A

1

7

High-throughput

0.479

High

1276904

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1289681

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1295589

MIB1
E3 ubiquitin-protein ligase MIB1

1

16

High-throughput

0.479

High

1313495

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1363878

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1400344

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

1428995

WWTR1
WW domain-containing transcription regulator protein 1

1

7

High-throughput

0.479

High

1432721

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.479

High

1434122

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

1446537

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

1446987

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1458282

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1458283

UBQL2
Ubiquilin-2

1

9

High-throughput

0.479

High

1458286

MYO6
Unconventional myosin-VI

1

13

High-throughput

0.479

High

1458287

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1458289

CD11A
Cyclin-dependent kinase 11A

1

4

High-throughput

0.479

High

1458290

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

1458292

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.479

High

1458294

EPN1
Epsin-1

1

20

Small-scale

0.479

High

1458295

NS1BP
Influenza virus NS1A-binding protein

1

2

High-throughput

0.479

High

50954

A1L1C6
LRRC7 protein

1

5

High-throughput

0.470

High

61765

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.458

High

939660

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

230455

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.457

High

64409

A6H8W8
Intersectin 2

1

19

High-throughput

0.445

High

127202

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

255259

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

619946

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

889351

NUMB
Protein numb homolog

1

19

Small-scale

0.445

High

896912

DYN2
Dynamin-2

1

12

High-throughput

0.445

High

935227

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

1220507

BTBD8
BTB/POZ domain-containing protein 8

1

7

High-throughput

0.445

High

1234997

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.445

High

1331920

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

High-throughput

0.445

High

1458285

CBLC
E3 ubiquitin-protein ligase CBL-C

1

14

High-throughput

0.445

High

1226548

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1458291

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

Small-scale

0.437

High

404938

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1458284

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025