Protein: EPS15
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)

Gene: EPS15
Organism: Homo sapiens
Interactions: 224
UniProt ID: P42566

Gene Ontology (top 5):
GO:0001921 - positive regulation of receptor recycling
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839804

STON2
Stonin-2

5

14

Small-scale

0.946

High

507647

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

14

Small-scale

0.751

High

839851

EPN1
Epsin-1

7

20

Small-scale

0.745

High

344644

AP2A1
AP-2 complex subunit alpha-1

7

20

Small-scale

0.744

High

839810

AP2M1
AP-2 complex subunit mu

6

14

High-throughput

0.738

High

362920

EGFR
Epidermal growth factor receptor

7

13

Small-scale

0.735

High

839725

AP2S1
AP-2 complex subunit sigma

5

13

High-throughput

0.720

High

323676

AP2A2
AP-2 complex subunit alpha-2

5

20

Small-scale

0.717

High

839709

CRK
Adapter molecule crk

5

19

Small-scale

0.716

High

839750

FCHO2
F-BAR domain only protein 2

4

20

Small-scale

0.699

High

839738

AP2B1
AP-2 complex subunit beta

4

20

High-throughput

0.699

High

155651

FCHO1
F-BAR domain only protein 1

4

20

Small-scale

0.698

High

169471

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

4

6

Small-scale

0.697

High

839708

EPS15
Epidermal growth factor receptor substrate 15

4

15

Small-scale

0.694

High

169995

AURKA
Aurora kinase A

4

5

High-throughput

0.694

High

839716

NUMB
Protein numb homolog

4

20

Small-scale

0.692

High

839768

ITSN1
Intersectin-1

4

16

Small-scale

0.681

High

839848

UBQL1
Ubiquilin-1

3

9

Small-scale

0.677

High

603872

CXA1
Gap junction alpha-1 protein

4

8

Small-scale

0.676

High

839814

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

3

13

Small-scale

0.674

High

839755

PICAL
Phosphatidylinositol-binding clathrin assembly protein

3

10

High-throughput

0.670

High

839737

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.667

High

483304

CLCB
Clathrin light chain B

3

9

High-throughput

0.667

High

839751

AP1B1
AP-1 complex subunit beta-1

3

20

Small-scale

0.667

High

839827

SPC25
Kinetochore protein Spc25

3

1

High-throughput

0.667

High

839723

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

3

12

Small-scale

0.662

High

839839

SH3B4
SH3 domain-binding protein 4

3

1

Small-scale

0.656

High

225783

AP1G1
AP-1 complex subunit gamma-1

2

20

Small-scale

0.629

High

839774

RUN3A
RUN domain-containing protein 3A

2

5

High-throughput

0.628

High

839788

LSR
Lipolysis-stimulated lipoprotein receptor

2

3

High-throughput

0.628

High

839811

STALP
AMSH-like protease

2

2

High-throughput

0.628

High

839835

NECP2
Adaptin ear-binding coat-associated protein 2

2

5

High-throughput

0.628

High

839840

EP15R
Epidermal growth factor receptor substrate 15-like 1

2

16

High-throughput

0.628

High

252752

AP180
Clathrin coat assembly protein AP180

2

11

Small-scale

0.619

High

483038

CLCA
Clathrin light chain A

2

9

High-throughput

0.611

High

839710

CRKL
Crk-like protein

2

14

High-throughput

0.611

High

839712

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

2

High-throughput

0.611

High

839724

PLK1
Serine/threonine-protein kinase PLK1

2

6

High-throughput

0.611

High

839743

CLH1
Clathrin heavy chain 1

2

8

Small-scale

0.611

High

839796

S2541
Mitochondrial carrier protein SCaMC-3L

3

1

High-throughput

0.609

High

505664

CC172
Coiled-coil domain-containing protein 172

2

0

High-throughput

0.602

High

619580

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

839765

RNPS1
RNA-binding protein with serine-rich domain 1

2

4

High-throughput

0.601

High

683972

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

14

Small-scale

0.597

High

839849

RNF11
RING finger protein 11

3

3

Small-scale

0.594

High

839809

OPTN
Optineurin

2

6

Small-scale

0.586

High

839838

ITSN2
Intersectin-2

2

16

High-throughput

0.586

High

159550

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

9

Small-scale

0.584

High

362198

ABL1
Tyrosine-protein kinase ABL1

2

11

High-throughput

0.584

High

536673

HSP7C
Heat shock cognate 71 kDa protein

2

6

High-throughput

0.584

High

839843

UBQL2
Ubiquilin-2

2

8

Small-scale

0.584

High

839846

MYO6
Unconventional myosin-VI

2

8

Small-scale

0.584

High

839777

SPOPL
Speckle-type POZ protein-like

1

6

Small-scale

0.578

High

431528

AP2A
Transcription factor AP-2-alpha

2

0

Small-scale

0.577

High

395643

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

828183

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

Small-scale

0.561

High

839730

CORO7
Coronin-7

1

3

Small-scale

0.561

High

839802

REPS2
RalBP1-associated Eps domain-containing protein 2

1

15

Small-scale

0.561

High

839817

RNF26
E3 ubiquitin-protein ligase RNF26

2

4

Small-scale

0.543

High

240985

PRKN
E3 ubiquitin-protein ligase parkin

1

11

Small-scale

0.536

High

171676

GAK
Cyclin-G-associated kinase

1

12

High-throughput

0.536

High

269948

AUXI
Auxilin

1

3

High-throughput

0.536

High

300555

KRT36
Keratin, type I cuticular Ha6

1

19

High-throughput

0.536

High

389123

FINC
Fibronectin

1

9

High-throughput

0.536

High

637384

FLNA
Filamin-A

1

6

High-throughput

0.536

High

772658

MYH9
Myosin-9

1

5

High-throughput

0.536

High

839733

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

839753

TRAF2
TNF receptor-associated factor 2

1

8

High-throughput

0.536

High

839767

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

839771

DREB
Drebrin

1

2

High-throughput

0.536

High

839780

MACC1
Metastasis-associated in colon cancer protein 1

1

1

High-throughput

0.536

High

839795

SYNPO
Synaptopodin

1

3

High-throughput

0.536

High

839812

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

839818

WNK3
Serine/threonine-protein kinase WNK3

1

3

High-throughput

0.536

High

839826

SYNCI
Syncoilin

1

16

High-throughput

0.536

High

839828

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.536

High

839831

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.536

High

839833

BMP2K
BMP-2-inducible protein kinase

1

15

High-throughput

0.536

High

839836

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

839842

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

839792

SPART
Spartin

1

9

Small-scale

0.527

High

650630

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

839713

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

839717

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.513

High

839830

ANLN
Anillin

1

0

High-throughput

0.513

High

839714

MTR1A
Melatonin receptor type 1A

1

4

High-throughput

0.508

High

718993

WEE1
Wee1-like protein kinase

1

9

High-throughput

0.501

High

839711

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.501

High

839721

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

839722

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

4

Small-scale

0.501

High

839732

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

839734

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

Small-scale

0.501

High

839736

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.501

High

839745

ANK2
Ankyrin-2

1

12

High-throughput

0.501

High

839761

EPN4
Clathrin interactor 1

1

20

Small-scale

0.501

High

839766

DLGP5
Disks large-associated protein 5

1

2

High-throughput

0.501

High

839769

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.501

High

839773

AR13B
ADP-ribosylation factor-like protein 13B

1

8

High-throughput

0.501

High

839783

S31E1
Spermatogenesis-associated protein 31E1

1

10

High-throughput

0.501

High

839822

UBQL3
Ubiquilin-3

1

8

High-throughput

0.501

High

839834

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.501

High

839844

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

2

Small-scale

0.501

High

839772

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

839781

RUFY4
RUN and FYVE domain-containing protein 4

1

16

High-throughput

0.489

High

839791

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

839803

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

839757

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.486

High

178731

SCAM1
Secretory carrier-associated membrane protein 1

1

1

Small-scale

0.481

High

75812

TM114
Transmembrane protein 114

1

0

High-throughput

0.480

High

839718

TSC2
Tuberin

1

0

High-throughput

0.480

High

839739

ABCA4
Retinal-specific phospholipid-transporting ATPase ABCA4

1

0

High-throughput

0.480

High

839797

DRAM1
DNA damage-regulated autophagy modulator protein 1

1

0

High-throughput

0.480

High

172543

XPO1
Exportin-1

1

6

High-throughput

0.479

High

227206

KRT86
Keratin, type II cuticular Hb6

1

13

High-throughput

0.479

High

246461

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.479

High

296454

STAM2
Signal transducing adapter molecule 2

1

18

Small-scale

0.479

High

300313

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.479

High

300635

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.479

High

300732

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.479

High

341748

K2C75
Keratin, type II cytoskeletal 75

1

9

High-throughput

0.479

High

385063

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

385246

K2C6A
Keratin, type II cytoskeletal 6A

1

13

High-throughput

0.479

High

407407

K2C1
Keratin, type II cytoskeletal 1

1

10

High-throughput

0.479

High

411522

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

425886

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.479

High

440426

FYN
Tyrosine-protein kinase Fyn

1

11

High-throughput

0.479

High

459491

PROF1
Profilin-1

1

1

High-throughput

0.479

High

476278

K1C16
Keratin, type I cytoskeletal 16

1

18

High-throughput

0.479

High

534747

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

539965

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.479

High

551542

K2C3
Keratin, type II cytoskeletal 3

1

11

High-throughput

0.479

High

555932

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

566111

K1C10
Keratin, type I cytoskeletal 10

1

18

High-throughput

0.479

High

566340

K2C5
Keratin, type II cytoskeletal 5

1

11

High-throughput

0.479

High

593934

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

611024

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

13

Small-scale

0.479

High

642688

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

648448

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

698233

MAP4
Microtubule-associated protein 4

1

6

High-throughput

0.479

High

710106

EPHA2
Ephrin type-A receptor 2

1

8

Small-scale

0.479

High

713921

PML
Protein PML

1

7

High-throughput

0.479

High

761341

HS71L
Heat shock 70 kDa protein 1-like

1

6

High-throughput

0.479

High

767603

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

771964

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

777420

K22E
Keratin, type II cytoskeletal 2 epidermal

1

11

High-throughput

0.479

High

783192

TRI23
E3 ubiquitin-protein ligase TRIM23

1

6

High-throughput

0.479

High

801205

HSPA9
Stress-70 protein, mitochondrial

1

10

High-throughput

0.479

High

830282

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

839715

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.479

High

839719

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

839720

DYN2
Dynamin-2

1

11

Small-scale

0.479

High

839726

RD23A
UV excision repair protein RAD23 homolog A

1

10

Small-scale

0.479

High

839731

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.479

High

839740

KRT83
Keratin, type II cuticular Hb3

1

13

High-throughput

0.479

High

839741

KRT85
Keratin, type II cuticular Hb5

1

13

High-throughput

0.479

High

839742

DAB2
Disabled homolog 2

1

20

Small-scale

0.479

High

839746

SC6A3
Sodium-dependent dopamine transporter

1

5

Small-scale

0.479

High

839747

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.479

High

839749

PRDX1
Peroxiredoxin-1

1

3

High-throughput

0.479

High

839752

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

16

Small-scale

0.479

High

839756

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

839758

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.479

High

839759

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.479

High

839760

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.479

High

839762

IMB1
Importin subunit beta-1

1

1

Small-scale

0.479

High

839763

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

839764

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.479

High

839770

OCLN
Occludin

1

2

Small-scale

0.479

High

839776

K2C79
Keratin, type II cytoskeletal 79

1

11

High-throughput

0.479

High

839779

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.479

High

839782

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

839784

RFIP2
Rab11 family-interacting protein 2

1

12

Small-scale

0.479

High

839786

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

839789

K2C73
Keratin, type II cytoskeletal 73

1

11

High-throughput

0.479

High

839790

MIB1
E3 ubiquitin-protein ligase MIB1

1

15

High-throughput

0.479

High

839793

STK40
Serine/threonine-protein kinase 40

1

3

Small-scale

0.479

High

839794

RHG18
Rho GTPase-activating protein 18

1

5

High-throughput

0.479

High

839801

NECP1
Adaptin ear-binding coat-associated protein 1

1

5

High-throughput

0.479

High

839805

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

839806

KRT35
Keratin, type I cuticular Ha5

1

20

High-throughput

0.479

High

839815

TRI56
E3 ubiquitin-protein ligase TRIM56

1

12

High-throughput

0.479

High

839821

EPN3
Epsin-3

1

20

Small-scale

0.479

High

839823

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

18

Small-scale

0.479

High

839824

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

839832

KRT82
Keratin, type II cuticular Hb2

1

13

High-throughput

0.479

High

839837

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

839841

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

839847

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

839850

DCAF1
DDB1- and CUL4-associated factor 1

1

4

High-throughput

0.479

High

376746

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

Small-scale

0.458

High

378842

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

457284

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

565207

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

839735

H4
Histone H4

1

0

High-throughput

0.458

High

839744

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

839775

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

839787

TMM17
Transmembrane protein 17

1

0

High-throughput

0.458

High

839819

KRA93
Keratin-associated protein 9-3

1

0

High-throughput

0.458

High

250977

PRP17
Pre-mRNA-processing factor 17

1

7

High-throughput

0.457

High

839727

AF10
Protein AF-10

1

4

High-throughput

0.457

High

839728

AF17
Protein AF-17

1

4

High-throughput

0.457

High

839813

LMTK3
Serine/threonine-protein kinase LMTK3

1

20

High-throughput

0.457

High

839748

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.457

High

64403

A6H8W8
Intersectin 2

1

19

High-throughput

0.445

High

72381

A9UF07
Tyrosine-protein kinase ABL1

1

12

High-throughput

0.445

High

300262

KT33A
Keratin, type I cuticular Ha3-I

1

20

High-throughput

0.445

High

410687

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

13

Small-scale

0.445

High

765214

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

839778

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.445

High

839785

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

839798

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

2

High-throughput

0.445

High

694827

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

839754

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.437

High

839808

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

839845

RCOR1
REST corepressor 1

1

1

High-throughput

0.437

High

839829

PALMD
Palmdelphin

1

1

High-throughput

0.408

High

839799

TAC2N
Tandem C2 domains nuclear protein

1

2

High-throughput

0.373

High

839729

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

2

0

High-throughput

0.328

High

839800

IN80E
INO80 complex subunit E

2

0

High-throughput

0.313

High

839820

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

0

High-throughput

0.279

Low

839825

ESF1
ESF1 homolog

1

0

High-throughput

0.249

Low

839807

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.232

Low

839816

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025