HitPredict

Interactor 1: BMP6 (P22004)
Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
Gene: BMP6

Interactor 2: AVR2B (Q13705)
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Gene: ACVR2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10504300
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001822 - kidney development GO:0030501 - positive regulation of bone mineralization GO:0030509 - BMP signaling pathway GO:0045669 - positive regulation of osteoblast differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 512
+	Hs
		602925 BMP6_HUMAN (1-513): 0: 576: 100.00		AVR2A_HUMAN (3-512): 2.84e-150: 441: 67.32
+	Hs
		602929 BMP6_HUMAN (1-513): 0: 576: 100.00		ACVR1_HUMAN (39-492): 3.02e-134: 400: 30.39
+	Hs
		602932 BMP6_HUMAN (1-513): 0: 576: 100.00		BMPR2_HUMAN (4-502): 3.62e-122: 384: 33.84
+	Hs
		122283 BMP6_HUMAN (1-513): 0: 576: 100.00		BMR1B_HUMAN (58-486): 1.94e-126: 380: 32.39
+	Hs
		602926 BMP6_HUMAN (1-513): 0: 576: 100.00		BMR1A_HUMAN (58-486): 1.16e-117: 358: 30.02
+	Hs
		574203 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Hs
		574181 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		AVR2A_HUMAN (3-512): 2.84e-150: 441: 67.32
+	Hs
		574199 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		ACVR1_HUMAN (39-492): 3.02e-134: 400: 30.39
+	Hs
		574204 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		BMPR2_HUMAN (4-502): 3.62e-122: 384: 33.84
+	Hs
		122282 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		BMR1B_HUMAN (58-486): 1.94e-126: 380: 32.39
+	Hs
		574186 BMP7_HUMAN (64-513): 4.73e-152: 442: 59.33		BMR1A_HUMAN (58-486): 1.16e-117: 358: 30.02
+	Hs
		792920 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		AVR2B_HUMAN (1-512): 1.04e-153: 450: 100.00
+	Hs
		646022 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		AVR2A_HUMAN (3-512): 2.84e-150: 441: 67.32
+	Hs
		792917 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		ACVR1_HUMAN (39-492): 3.02e-134: 400: 30.39
+	Hs
		792921 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		BMPR2_HUMAN (4-502): 3.62e-122: 384: 33.84
+	Hs
		122285 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		BMR1B_HUMAN (58-486): 1.94e-126: 380: 32.39
+	Dm
		646113 60A_DROME (53-513): 2.85e-126: 378: 32.00		Q24326_DROME (101-497): 1.15e-111: 344: 31.38
+	Dm
		646114 60A_DROME (53-513): 2.85e-126: 378: 32.00		Q95SI0_DROME (50-497): 4.58e-112: 343: 29.30
+	Dm
		646115 60A_DROME (53-513): 2.85e-126: 378: 32.00		Q95U21_DROME (59-481): 1.61e-110: 340: 29.15
+	Hs
		738309 GDF5_HUMAN (2-512): 2.63e-113: 346: 24.57		BMR1A_HUMAN (58-486): 1.16e-117: 358: 30.02