HitPredict

Interactor 1: A5D6Q2 (A5D6Q2)
Ncoa3 protein
Gene: Ncoa3

Interactor 2: NR1I2 (O54915)
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PXR) (Pregnane X receptor)
Gene: NR1I2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0016922 - nuclear receptor binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1353 Mm			1 431
+	Mm
		222608 Q05BA5_MOUSE (1-1353): 1.49e-167: 540: 100.00		NR1I2_MOUSE (1-431): 5.34e-125: 370: 100.00
+	Mm
		60493 A5D6Q2_MOUSE (1-1353): 4.78e-168: 540: 100.00		RORB_MOUSE (37-426): 5.09e-87: 274: 23.09
+	Mm
		985522 Q05BA5_MOUSE (1-1353): 1.49e-167: 540: 100.00		RORB_MOUSE (37-426): 5.09e-87: 274: 23.09
+	Hs
		265886 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR1I2_HUMAN (1-429): 1.99e-118: 354: 77.21
+	Hs
		510000 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		VDR_HUMAN (16-429): 1.76e-99: 305: 37.56
+	Hs
		874407 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR1H2_HUMAN (13-430): 1.67e-96: 298: 24.65
+	Hs
		490120 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		COT1_HUMAN (4-429): 1.13e-96: 297: 21.11
+	Hs
		500381 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARB_HUMAN (3-431): 3.77e-96: 297: 26.44
+	Hs
		1025276 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR1H3_HUMAN (5-430): 1.44e-94: 293: 22.81
+	Hs
		130340 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR5A2_HUMAN (4-426): 1.05e-92: 291: 20.00
+	Hs
		488043 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARA_HUMAN (3-431): 3.75e-92: 287: 27.59
+	Hs
		500455 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		THA_HUMAN (3-399): 2.5e-91: 286: 25.98
+	Hs
		587212 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RXRA_HUMAN (26-428): 9.68e-92: 286: 18.97
+	Hs
		611537 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR4A1_HUMAN (3-429): 3.47e-90: 286: 22.15
+	Hs
		370839 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		ESR1_HUMAN (3-429): 2.69e-89: 284: 18.74
+	Hs
		740635 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARG_HUMAN (1-428): 1.36e-88: 279: 21.30
+	Hs
		500511 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		THB_HUMAN (4-428): 1.31e-88: 278: 26.73
+	Hs
		530818 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARG_HUMAN (2-430): 4.09e-87: 274: 23.91
+	Hs
		975487 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARD_HUMAN (33-428): 4.92e-86: 271: 20.50
+	Hs
		992458 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARA_HUMAN (10-428): 3.3e-85: 269: 20.98