Protein: FXL16
F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16)

Gene: FXL16, FBXL16
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q8N461

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992253

SKP1
S-phase kinase-associated protein 1

5

20

Small-scale

0.706

High

1325802

DAAM1
Disheveled-associated activator of morphogenesis 1

3

4

High-throughput

0.662

High

1161147

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.656

High

507275

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

12

High-throughput

0.628

High

1325786

FXL18
F-box/LRR-repeat protein 18

2

2

High-throughput

0.628

High

1325794

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.618

High

991063

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

4

Small-scale

0.611

High

1161325

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.589

High

1270472

MARK2
Serine/threonine-protein kinase MARK2

1

0

High-throughput

0.578

High

343612

OXSR1
Serine/threonine-protein kinase OSR1

1

5

High-throughput

0.575

High

858683

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

7

High-throughput

0.575

High

1325788

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

9

High-throughput

0.575

High

537511

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.536

High

717900

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.536

High

977542

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

4

High-throughput

0.536

High

994298

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.536

High

1023834

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.536

High

1325792

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

1

High-throughput

0.536

High

1325799

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

138853

STK25
Serine/threonine-protein kinase 25

1

4

High-throughput

0.514

High

281530

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

20

High-throughput

0.514

High

322427

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

62983

POTEF
POTE ankyrin domain family member F

1

4

High-throughput

0.489

High

159742

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.445

High

255837

USO1
General vesicular transport factor p115

1

2

High-throughput

0.445

High

301925

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

2

High-throughput

0.445

High

716126

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

840971

ABL2
Tyrosine-protein kinase ABL2

1

2

High-throughput

0.445

High

1129450

PUM1
Pumilio homolog 1

1

1

High-throughput

0.445

High

1179229

ERC6L
DNA excision repair protein ERCC-6-like

1

2

High-throughput

0.445

High

1258439

UN13D
Protein unc-13 homolog D

1

2

High-throughput

0.445

High

1278196

CLAP1
CLIP-associating protein 1

1

2

High-throughput

0.445

High

1289805

AACS
Acetoacetyl-CoA synthetase

1

1

High-throughput

0.445

High

1325421

SYNPO
Synaptopodin

1

1

High-throughput

0.445

High

1325782

CTF18
Chromosome transmission fidelity protein 18 homolog

1

7

High-throughput

0.445

High

1325791

CA198
Uncharacterized protein C1orf198

1

1

High-throughput

0.445

High

1325801

TTF2
Transcription termination factor 2

1

3

High-throughput

0.445

High

1325803

SNX8
Sorting nexin-8

1

2

High-throughput

0.445

High

1325804

FHOD1
FH1/FH2 domain-containing protein 1

1

4

High-throughput

0.445

High

372568

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.437

High

291431

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.426

High

359841

DYR
Dihydrofolate reductase

1

0

High-throughput

0.426

High

663365

KTHY
Thymidylate kinase

1

0

High-throughput

0.426

High

1125899

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.426

High

1139342

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1177599

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.426

High

1248624

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1325781

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.426

High

1325783

SYMPK
Symplekin

1

0

High-throughput

0.426

High

1325790

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

229454

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

2

High-throughput

0.407

High

249487

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.407

High

827444

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.407

High

928642

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.407

High

1152817

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

3

High-throughput

0.407

High

1177027

INF2
Inverted formin-2

1

4

High-throughput

0.407

High

1180082

SMTL2
Smoothelin-like protein 2

1

3

High-throughput

0.407

High

1180157

QRIC1
Transcriptional regulator QRICH1

1

2

High-throughput

0.407

High

1238272

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

3

High-throughput

0.407

High

1257525

TMTC3
Protein O-mannosyl-transferase TMTC3

1

7

High-throughput

0.407

High

1276215

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.407

High

1325787

WRIP1
ATPase WRNIP1

1

3

High-throughput

0.407

High

1325795

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.407

High

1325798

XPO7
Exportin-7

1

4

High-throughput

0.407

High

296722

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

665999

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.279

Low

1291628

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1325800

HPCL4
Hippocalcin-like protein 4

1

0

Small-scale

0.249

Low

947018

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

329305

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.232

Low

789923

FDFT
Squalene synthase

1

0

High-throughput

0.232

Low

851950

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.232

Low

1111604

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.232

Low

1146317

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.232

Low

1165256

RTL8B
Retrotransposon Gag-like protein 8B

1

0

High-throughput

0.232

Low

1205719

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.232

Low

1293952

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.232

Low

1324240

ARM10
Armadillo repeat-containing protein 10

1

0

High-throughput

0.232

Low

1325784

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.232

Low

1325785

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.232

Low

1325789

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.232

Low

1325793

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.232

Low

1325796

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.232

Low

1325797

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025