HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1058 Hs			1 1024
+	Hs
		48142 UBA6_HUMAN (12-1057): 0: 1037: 41.09		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		125155 UBA1_HUMAN (1-1058): 0: 1358: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		607135 UBA1_HUMAN (1-1058): 0: 1358: 100.00		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		48079 UBA6_HUMAN (12-1057): 0: 1037: 41.09		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		48128 UBA6_HUMAN (12-1057): 0: 1037: 41.09		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		1354311 SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1353972 SAE1_HUMAN (444-719): 5.18e-64: 222: 16.00		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1252665 UBA3_HUMAN (847-1018): 1.74e-12: 72.9: 17.13		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		983261 SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		983260 SAE1_HUMAN (444-719): 5.18e-64: 222: 16.00		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37